{"id":"W2518584643","doi":"10.1139/gen-2016-0069","title":"The <i>HtrA2 Drosophila</i> model of Parkinson’s disease is suppressed by the pro-survival <i>Bcl-2</i> <i>Buffy</i>","year":2016,"lang":"en","type":"article","venue":"Genome","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland","keywords":"Biology; Drosophila melanogaster; Buffy coat; Caspase; Phenotype; Dopaminergic; Loss function; Cell biology; Apoptosis; Programmed cell death; Genetics; Neuroscience; Immunology; Gene; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024203,0.0001885034,0.0001310942,0.00001088938,0.0002021071,0.00003074623,0.0005420207,0.00007668681,0.0000143441],"category_scores_gemma":[0.00004301657,0.00009188846,0.0001332696,0.00006413441,0.0002505085,0.000005753277,0.00016045,0.00005565563,0.00001952484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008781331,"about_ca_system_score_gemma":0.0001323292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004908984,"about_ca_topic_score_gemma":0.000004981228,"domain_scores_codex":[0.9987596,0.00005869102,0.0002558669,0.0003341855,0.0002529583,0.0003386458],"domain_scores_gemma":[0.9990965,0.00003275369,0.0001130006,0.0005689715,0.00007536422,0.0001134313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002918996,0.00005214043,0.001516731,0.00001629923,0.00005541857,5.904031e-7,0.00007025721,0.00002159875,0.9689311,0.0002196166,0.02791021,0.000914136],"study_design_scores_gemma":[0.001061933,0.00009995493,0.002751956,0.00001468143,0.0000427109,0.000001479514,0.00006038387,0.0000619284,0.1272477,0.002485121,0.8658119,0.0003601995],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9451323,0.01099774,0.003083138,0.02748176,0.0003906588,0.001011634,0.0007684203,0.00003674623,0.01109758],"genre_scores_gemma":[0.9895949,0.002759653,0.00006439854,0.001524938,0.00009464232,0.00007572758,0.00005763986,0.00002832959,0.00579977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8416834,"threshold_uncertainty_score":0.3747103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100888580868709,"score_gpt":0.2115190254282501,"score_spread":0.2014301673413792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}