{"id":"W2518647359","doi":"10.1111/cbdd.12861","title":"Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto‐5′‐nucleotidase","year":2016,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Higher Education Commission, Pakistan","keywords":"Alkaline phosphatase; Hypophosphatasia; Chemistry; 5'-nucleotidase; Enzyme; Isozyme; Nucleotidase; Molecular biology; Biochemistry; Phosphatase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002467675,0.000591626,0.0003875668,0.0003094781,0.0001321769,0.000142961,0.0003295342,0.0003543728,0.0008519836],"category_scores_gemma":[0.0001678216,0.0002025738,0.0002587336,0.0002834674,0.0001964511,0.0001977912,0.0001738217,0.0005719501,0.0003215993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002723431,"about_ca_system_score_gemma":0.0002587901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007661551,"about_ca_topic_score_gemma":0.001395374,"domain_scores_codex":[0.9997911,0.00005372286,0.00001928474,0.00003289379,0.00005476976,0.00004812675],"domain_scores_gemma":[0.9998913,0.00001853137,0.0000282356,0.000009655892,0.00002052748,0.00003176119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004370276,0.0001514102,0.0002422258,0.0002330441,0.00001711886,0.0001814535,0.00003707617,0.0005729855,0.9882814,0.0004473676,0.0001572717,0.009241514],"study_design_scores_gemma":[0.000166733,0.002355024,0.001604322,0.00002285929,0.00003951299,0.0007292706,0.00002715287,0.0007390562,0.9836919,0.00006454869,0.01054341,0.00001627328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9350781,0.03958666,0.01496366,0.0003038819,0.000181602,0.0002460587,0.0006269748,0.0003079306,0.008705164],"genre_scores_gemma":[0.9723747,0.01308445,0.009875992,0.0001697733,0.00005265364,0.0001466904,0.0009182622,0.00001967814,0.003357818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008519836,"threshold_uncertainty_score":0.002850175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01961411294992388,"score_gpt":0.3011243153515843,"score_spread":0.2815102024016605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}