{"id":"W2518647359","doi":"10.1111/cbdd.12861","title":"Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto‐5′‐nucleotidase","year":2016,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Higher Education Commission, Pakistan","keywords":"Alkaline phosphatase; Hypophosphatasia; Chemistry; 5'-nucleotidase; Enzyme; Isozyme; Nucleotidase; Molecular biology; Biochemistry; Phosphatase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004934578,0.0002728794,0.0006296031,0.0001081705,0.00005833575,0.000005131463,0.0001499755,0.0001618252,0.0002312016],"category_scores_gemma":[0.001786791,0.0001635961,0.0001110111,0.0002184859,0.001248792,0.00007382173,0.0002594223,0.0001835776,0.0001428756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005691454,"about_ca_system_score_gemma":0.0001219512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006693447,"about_ca_topic_score_gemma":8.482975e-7,"domain_scores_codex":[0.9982359,0.000111406,0.0004486752,0.0005142075,0.0001902919,0.0004994684],"domain_scores_gemma":[0.9979016,0.00108842,0.000133988,0.0003861132,0.0001650375,0.0003248865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008389589,0.0002466046,0.002759019,0.00009753523,0.0002138777,0.0000580255,0.00008285935,1.475727e-7,0.9596651,0.001005594,0.01457627,0.02045601],"study_design_scores_gemma":[0.0024256,0.0003222892,0.0001331393,0.0001959589,0.00009881376,0.00005754746,0.00004441073,0.00003687953,0.9901504,0.002319592,0.004024799,0.000190596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725224,0.0185162,0.0008213922,0.006857139,0.0001027127,0.0007077813,0.0002053048,0.000115986,0.000151092],"genre_scores_gemma":[0.9948097,0.002011819,0.002336815,0.0003344395,0.0001432876,0.00003954414,0.00007310103,0.00002844989,0.0002228322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03048528,"threshold_uncertainty_score":0.6671255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01961411294992388,"score_gpt":0.3011243153515843,"score_spread":0.2815102024016605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}