{"id":"W2518717287","doi":"10.1038/mtna.2016.68","title":"Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Sclerostin; Gene silencing; Gene knockdown; Osteocyte; Cell biology; Chemistry; Osteoblast; Small interfering RNA; RNA interference; Wnt signaling pathway; In vivo; In vitro; Transfection; Gene; Biology; Signal transduction; RNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416527,0.0003608289,0.0003489,0.0001869866,0.0001390595,0.0002559247,0.0001428388,0.0004032451,0.0007118783],"category_scores_gemma":[0.0001313662,0.0001715347,0.0002826058,0.0001066086,0.0002703613,0.0001539013,0.0001497591,0.00039223,0.000311515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296545,"about_ca_system_score_gemma":0.0003419078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096115,"about_ca_topic_score_gemma":0.001900257,"domain_scores_codex":[0.9998354,0.0000219046,0.00001620119,0.0000365656,0.00005878322,0.00003113509],"domain_scores_gemma":[0.99991,0.00002351765,0.00002382521,0.000007473685,0.00001858855,0.00001656881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002345127,0.000009353427,0.00001769717,0.00001171482,0.0000017311,0.00001465322,0.000006325744,0.00003296198,0.9995572,0.00002766328,0.0000102119,0.0002869781],"study_design_scores_gemma":[0.000008816218,0.0001053902,0.000297745,0.000001554117,0.000004929703,0.00002973695,0.00000445903,0.0004645944,0.9986451,0.000008894256,0.0004276613,0.000001164286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849493,0.0012686,0.01097595,0.0001164026,0.00005090548,0.00006846228,0.0002022077,0.0001213842,0.002246746],"genre_scores_gemma":[0.985661,0.001050544,0.007896993,0.00007395308,0.000009018433,0.0001086716,0.0003184369,0.00006502529,0.004816342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096115,"threshold_uncertainty_score":0.002391875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007169913584867142,"score_gpt":0.2234887960424006,"score_spread":0.2163188824575334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}