{"id":"W2518717287","doi":"10.1038/mtna.2016.68","title":"Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Sclerostin; Gene silencing; Gene knockdown; Osteocyte; Cell biology; Chemistry; Osteoblast; Small interfering RNA; RNA interference; Wnt signaling pathway; In vivo; In vitro; Transfection; Gene; Biology; Signal transduction; RNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856496,0.0001451872,0.0002433852,0.0001149196,0.00001680206,0.000004981733,0.0001204082,0.00009771291,0.00001982428],"category_scores_gemma":[0.00007119263,0.0001188926,0.00007507929,0.0001652762,0.00009326203,0.000009763333,0.0001097218,0.00003351992,0.000003787202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001602479,"about_ca_system_score_gemma":0.00002864713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006193062,"about_ca_topic_score_gemma":0.0000269989,"domain_scores_codex":[0.9989979,0.00008645558,0.0003079569,0.0002864549,0.0001320324,0.0001891759],"domain_scores_gemma":[0.9993898,0.00002802688,0.00009925416,0.0002661652,0.0001476607,0.00006911731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005970889,0.00007382231,0.007679348,0.00002097378,0.00003099831,0.000002385935,0.0003323741,0.00004443639,0.9752783,0.00001772318,0.00003219537,0.01589038],"study_design_scores_gemma":[0.0009612676,0.002146084,0.008830372,0.0002263784,0.000007484483,0.000001940003,0.00009243032,0.00000672634,0.9874893,0.00003163444,0.00006673892,0.0001395837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982496,0.0004084288,0.0007554402,0.00009550307,0.0000370705,0.0003508944,0.00002878183,0.000004500041,0.00006978901],"genre_scores_gemma":[0.9991476,0.000172996,0.0003534467,0.0002377692,0.00002185844,0.00002253795,0.000002370159,0.00002002233,0.00002137796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0157508,"threshold_uncertainty_score":0.4848301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007169913584867142,"score_gpt":0.2234887960424006,"score_spread":0.2163188824575334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}