{"id":"W2518749129","doi":"10.1128/mbio.01120-16","title":"Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence","year":2016,"lang":"en","type":"article","venue":"mBio","topic":"Malaria Research and Control","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada","keywords":"Plasmodium falciparum; Thrombin; Cerebral Malaria; Serine protease; Bacterial adhesin; Receptor; Chemistry; Cell biology; Biology; Microbiology; Protease; Biochemistry; Malaria; Immunology; Virulence; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262085,0.0002716595,0.0001865218,0.00009073592,0.00008048244,0.0001389983,0.0002030106,0.0001728349,0.001938823],"category_scores_gemma":[0.0001663771,0.00005378031,0.0001421136,0.00009736354,0.0001222489,0.00007360116,0.0001256243,0.0003041771,0.0003170143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336061,"about_ca_system_score_gemma":0.0001331455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003834115,"about_ca_topic_score_gemma":0.0003800387,"domain_scores_codex":[0.9998835,0.0000311886,0.0000100769,0.00001593319,0.00002782455,0.00003141616],"domain_scores_gemma":[0.9999328,0.00002590442,0.00001727902,0.000006066849,0.000008095457,0.000009822623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003668066,0.00009247712,0.0002275031,0.00008121612,0.00001057007,0.00006545782,0.00001409115,0.00007597,0.994988,0.00004824767,0.00009940439,0.003930338],"study_design_scores_gemma":[0.00006089886,0.001726131,0.005107564,0.000007795602,0.00001510373,0.0003741709,0.00001070329,0.000815478,0.9899597,0.0000204255,0.001899265,0.000002806441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926278,0.004653968,0.001163431,0.00008620727,0.00004590876,0.00003105483,0.0001698292,0.00004485491,0.00117703],"genre_scores_gemma":[0.9965503,0.001067296,0.0008634924,0.00004620558,0.00002005251,0.0000223289,0.0003751235,0.000006383515,0.001048797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001938823,"threshold_uncertainty_score":0.006485999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02201116812945558,"score_gpt":0.2696623418710871,"score_spread":0.2476511737416315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}