{"id":"W2518749129","doi":"10.1128/mbio.01120-16","title":"Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence","year":2016,"lang":"en","type":"article","venue":"mBio","topic":"Malaria Research and Control","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada","keywords":"Plasmodium falciparum; Thrombin; Cerebral Malaria; Serine protease; Bacterial adhesin; Receptor; Chemistry; Cell biology; Biology; Microbiology; Protease; Biochemistry; Malaria; Immunology; Virulence; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002858704,0.0001461079,0.0003588919,0.00008943122,0.00004139602,0.00001127709,0.0001579761,0.0001257148,0.001039817],"category_scores_gemma":[0.0002876761,0.00009130209,0.00009809583,0.0001540659,0.0001728653,0.0001021155,0.00007897639,0.0001655799,0.0003402843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004972233,"about_ca_system_score_gemma":0.0001957497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009308813,"about_ca_topic_score_gemma":0.00003937193,"domain_scores_codex":[0.9984862,0.00006750785,0.0002811353,0.0002808206,0.0004495092,0.0004347877],"domain_scores_gemma":[0.9990907,0.00006763208,0.00008564073,0.0004168643,0.0001196904,0.0002194441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009374159,0.0001661496,0.0004389096,0.000132462,0.00005631281,0.00003753055,0.00005390987,5.027156e-8,0.9877033,0.002474681,0.003531066,0.004468176],"study_design_scores_gemma":[0.004561105,0.0008439427,0.003132674,0.0003799096,0.00002290948,0.0000232951,0.0000325469,0.00001604664,0.9871093,0.0003250997,0.003437774,0.0001153703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652581,0.0002001713,0.0005798679,0.008647251,0.00008023138,0.001381961,0.00005408718,0.0000894909,0.0237089],"genre_scores_gemma":[0.9885227,0.00003879606,0.0002149431,0.0001208102,0.00008652906,0.00008759496,0.000003697244,0.00001973766,0.01090516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02326469,"threshold_uncertainty_score":0.9998733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02201116812945558,"score_gpt":0.2696623418710871,"score_spread":0.2476511737416315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}