{"id":"W2518765238","doi":"10.1200/jco.2016.68.5776","title":"PANCREOX: A Randomized Phase III Study of Fluorouracil/Leucovorin With or Without Oxaliplatin for Second-Line Advanced Pancreatic Cancer in Patients Who Have Received Gemcitabine-Based Chemotherapy","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"American Society of Clinical Oncology","keywords":"Oxaliplatin; Medicine; Gemcitabine; Folinic acid; Fluorouracil; Regimen; Internal medicine; Clinical endpoint; Phases of clinical research; Progression-free survival; Pancreatic cancer; Chemotherapy; Oncology; Adverse effect; Performance status; Gastroenterology; Surgery; Cancer; Colorectal cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.007126857,0.0003402266,0.007210861,0.0003502315,0.0000518382,0.000006146525,0.0002670489,0.0004179841,0.0008539981],"category_scores_gemma":[0.008659783,0.0001625026,0.0004722807,0.000253354,0.0005443829,0.0001626981,0.00003274774,0.0007023922,0.000001838717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003813231,"about_ca_system_score_gemma":0.003659209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001075434,"about_ca_topic_score_gemma":0.001171357,"domain_scores_codex":[0.9922626,0.001562308,0.004549511,0.0004183868,0.0006911082,0.0005160836],"domain_scores_gemma":[0.9801669,0.01376443,0.003597782,0.0003864208,0.001643901,0.0004405495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5504007,0.007855962,0.3766908,0.0000830258,0.001109047,0.00006768531,0.0003826414,0.00001201603,0.0002658306,0.0000024341,0.0001410666,0.06298875],"study_design_scores_gemma":[0.7849469,0.09378986,0.1158818,0.0008874309,0.001138791,0.00001612231,0.0004571595,0.001498484,0.0004211457,0.00005768585,0.0007236899,0.0001809294],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905491,0.0001339174,0.001808312,0.002242582,0.000232755,0.004719192,0.00003238236,0.00001014316,0.0002716336],"genre_scores_gemma":[0.989172,0.0005067277,0.00681768,0.0006887669,0.0003681009,0.0004076379,0.000004870087,0.000050069,0.001984124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.260809,"threshold_uncertainty_score":0.9996907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09762290404530811,"score_gpt":0.4899991221354943,"score_spread":0.3923762180901862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}