{"id":"W2518883904","doi":"10.1016/j.cmet.2016.08.006","title":"Never Waste a Good Crisis: Confronting Reproducibility in Translational Research","year":2016,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Health and Medical Research Impacts","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reproducibility; Translational research; Engineering ethics; Medicine; Engineering; Chemistry; Pathology; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7321649,0.002104401,0.008866589,0.01046797,0.01495131,0.03281675,0.0140717,0.0300152,0.00720494],"category_scores_gemma":[0.8642658,0.00347167,0.003882761,0.006180644,0.1391955,0.04819931,0.0348075,0.06264162,0.003233609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01324844,"about_ca_system_score_gemma":0.05061632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005880193,"about_ca_topic_score_gemma":0.006265756,"domain_scores_codex":[0.2898291,0.5134073,0.03991808,0.03846715,0.1119327,0.006445734],"domain_scores_gemma":[0.04298203,0.7700803,0.02567382,0.1040055,0.04917329,0.008085063],"domain_codex":"methods","domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001623706,0.0006622805,0.02499286,0.00626871,0.002541736,0.001255587,0.03389416,0.002740702,0.001385173,0.4921316,0.2078523,0.2246512],"study_design_scores_gemma":[0.0003530569,0.000245341,0.003618274,0.00465428,0.000326613,0.000571544,0.004116395,0.002443431,0.0009087734,0.8838259,0.0986219,0.0003145275],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.005321922,0.0315933,0.05010922,0.8819052,0.01938882,0.0002729419,0.0002239285,0.0004673074,0.01071734],"genre_scores_gemma":[0.3441098,0.01602891,0.1156409,0.4561052,0.0584561,0.002770013,0.0003959066,0.001531475,0.004961576],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2678351,"threshold_uncertainty_score":0.3302884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2159672159470531,"score_gpt":0.4533174153073433,"score_spread":0.2373501993602902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}