{"id":"W2519270966","doi":"10.1016/j.cels.2016.08.008","title":"Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci","year":2016,"lang":"en","type":"article","venue":"Cell Systems","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"DNA damage; Biology; Phenomics; Saccharomyces cerevisiae; Computational biology; Genome; Functional genomics; Mutant; DNA; Genomics; Genetics; Context (archaeology); Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006990067,0.0006217127,0.0009127459,0.0005878751,0.0003808638,0.00114813,0.001058594,0.000795526,0.001178746],"category_scores_gemma":[0.0006070975,0.0004840557,0.0004566618,0.0006365542,0.0007373151,0.0007068187,0.0008706772,0.001439924,0.0004601769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071576,"about_ca_system_score_gemma":0.0004312823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001580869,"about_ca_topic_score_gemma":0.004105595,"domain_scores_codex":[0.9995492,0.00007686242,0.00003476024,0.0001380503,0.0001569624,0.00004413669],"domain_scores_gemma":[0.9993012,0.0003003267,0.00009062246,0.0001334401,0.000107265,0.0000671817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002754457,0.00002149291,0.0004473658,0.00005120595,0.000009207718,0.00001932731,0.00001876564,0.0004820493,0.9963028,0.0004265714,0.00006044103,0.002133028],"study_design_scores_gemma":[0.0000105379,0.00006106585,0.005201675,0.000006061978,0.00001590616,0.0001302845,0.00004671194,0.01817908,0.9742498,0.0007797985,0.001297621,0.00002154202],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5900374,0.001781538,0.4000653,0.0005541008,0.0001092473,0.0002193954,0.003140938,0.001733283,0.002358861],"genre_scores_gemma":[0.7812825,0.002006074,0.2118405,0.0002609406,0.00003471349,0.000382443,0.001286915,0.0004027794,0.002503133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580869,"threshold_uncertainty_score":0.00777483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384747718759306,"score_gpt":0.2543623934573078,"score_spread":0.2158876215813772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}