{"id":"W2519305629","doi":"10.2196/resprot.6346","title":"Protocol Outlines for Parts 1 and 2 of the Prospective Endoscopy III Study for the Early Detection of Colorectal Cancer: Validation of a Concept Based on Blood Biomarkers","year":2016,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Augustinus Fonden; Abbott Laboratories","keywords":"Colorectal cancer; Medicine; Protocol (science); Prospective cohort study; Medical physics; Cancer; Oncology; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347188,0.0001285212,0.0002952862,0.0001487561,0.0001920618,0.00001530653,0.0001413483,0.00007896536,0.000009832496],"category_scores_gemma":[0.0007248067,0.00006179319,0.0001210026,0.0004361093,0.0003946558,0.00006563597,0.00005015081,0.0001363093,7.514215e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009401743,"about_ca_system_score_gemma":0.0003163352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000286353,"about_ca_topic_score_gemma":0.0001559292,"domain_scores_codex":[0.998181,0.0002762315,0.0003890861,0.0003055019,0.0006155361,0.0002325813],"domain_scores_gemma":[0.9971163,0.00113689,0.0003254655,0.0003047634,0.001065393,0.00005113443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2644755,0.002577246,0.1338952,0.001768669,0.0004144261,5.070277e-7,0.001935949,0.00003242657,0.5475385,0.00003395302,0.0001760242,0.04715158],"study_design_scores_gemma":[0.01798202,0.05455253,0.05038742,0.001365641,0.0000373768,8.740589e-7,0.0002446152,0.0005325874,0.8744223,0.00006984758,0.000343716,0.00006107569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2594839,0.000001438436,0.0006662119,0.000159411,0.00001093484,0.7395845,0.00005827805,0.00001461235,0.00002065471],"genre_scores_gemma":[0.4927749,5.886462e-8,0.00004688261,0.000001835799,0.0000375059,0.5070944,2.840291e-7,0.0000105889,0.00003355991],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.3268838,"threshold_uncertainty_score":0.2519853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176892248812117,"score_gpt":0.4801875407096443,"score_spread":0.3624983158284327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}