{"id":"W2519331805","doi":"10.1242/jcs.183541","title":"Sortilin regulates sorting and secretion of Sonic hedgehog","year":2016,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Clinical Research Institute; University of Toronto; University Health Network; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Helmholtz-Gemeinschaft","keywords":"Biology; Sonic hedgehog; Secretion; Hedgehog; Sorting; Cell biology; Hedgehog signaling pathway; Evolutionary biology; Signal transduction; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183327,0.0002963295,0.0001546117,0.0002619137,0.0002213877,0.0004366892,0.0001965419,0.0002677949,0.0007048744],"category_scores_gemma":[0.00007782559,0.0001984213,0.0001886713,0.00009979833,0.0002159255,0.0002556859,0.0002601542,0.0002940785,0.0004297004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006351316,"about_ca_system_score_gemma":0.0002851936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008893001,"about_ca_topic_score_gemma":0.001174598,"domain_scores_codex":[0.9998885,0.0000189552,0.000008507054,0.0000216982,0.00003390703,0.00002849828],"domain_scores_gemma":[0.9999135,0.000009474625,0.00002167539,0.00000533985,0.00001572646,0.00003428219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009416906,0.000005463718,0.0003192769,0.00003268522,0.00000371752,0.00006537978,0.00001406596,0.00003522601,0.9982404,0.0002336544,0.00003686662,0.0009192054],"study_design_scores_gemma":[0.00001186405,0.00006625178,0.0157194,0.000007021303,0.00001764183,0.0003715787,0.0000567542,0.001110339,0.9789056,0.0001086266,0.003619526,0.000005378976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917658,0.002600627,0.002531402,0.000114623,0.00002891652,0.00001516646,0.0002800837,0.00007618692,0.002587215],"genre_scores_gemma":[0.9921458,0.00155985,0.001164579,0.00005236139,0.000006000638,0.000013571,0.0003930877,0.00002907452,0.004635586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008893001,"threshold_uncertainty_score":0.004608214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009696124769294589,"score_gpt":0.2457161570785535,"score_spread":0.2360200323092589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}