{"id":"W2519427278","doi":"10.1038/srep33179","title":"The Mechanism of Hsp90 ATPase Stimulation by Aha1","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Hsp90; Mechanism (biology); Stimulation; ATPase; Chemistry; Computational biology; Computer science; Neuroscience; Biology; Biochemistry; Heat shock protein; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001470146,0.0000683297,0.00006648625,0.0000307707,0.0002165292,0.00004899656,0.0001463149,0.00006918854,0.00004532839],"category_scores_gemma":[0.0005329258,0.0000375496,0.00005497173,0.0001148107,0.0002274716,0.000004607337,0.0001238058,0.0000308723,0.00001345802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001513806,"about_ca_system_score_gemma":0.0001406501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001157101,"about_ca_topic_score_gemma":0.00001246186,"domain_scores_codex":[0.9986675,0.00006438692,0.0002697244,0.0003904532,0.0003827375,0.0002251617],"domain_scores_gemma":[0.9987327,0.00002025275,0.0001113999,0.0008503359,0.0002102406,0.00007504286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001096822,0.00001787875,0.0002628826,0.000003640607,0.000008153341,0.000007231372,0.000007244858,0.000002003766,0.9767005,0.0001308144,0.01624975,0.006598915],"study_design_scores_gemma":[0.00007956024,0.00005098035,0.00006452785,0.000007783051,0.00000209442,0.00001537846,0.000006578633,0.00001916173,0.8739232,0.002813021,0.1229661,0.00005158332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903319,0.0002594434,0.00688049,0.0003659344,0.0009562457,0.000324635,0.000007751057,0.00000913572,0.000864484],"genre_scores_gemma":[0.985281,0.00001739585,0.0001196191,0.000007104228,0.00004040609,0.00002185155,0.0000277474,0.000009722939,0.01447516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1067163,"threshold_uncertainty_score":0.166539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204586131142632,"score_gpt":0.2795427688886821,"score_spread":0.2674969075772557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}