{"id":"W2519427278","doi":"10.1038/srep33179","title":"The Mechanism of Hsp90 ATPase Stimulation by Aha1","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Hsp90; Mechanism (biology); Stimulation; ATPase; Chemistry; Computational biology; Computer science; Neuroscience; Biology; Biochemistry; Heat shock protein; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849372,0.0004036143,0.0003049317,0.0002420606,0.0002856383,0.0003924202,0.0004238947,0.0004981955,0.001398208],"category_scores_gemma":[0.0001214087,0.0002019886,0.0005365545,0.0001256539,0.0003142132,0.0004775265,0.000504963,0.0009004106,0.0007357628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895115,"about_ca_system_score_gemma":0.0001986367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026005,"about_ca_topic_score_gemma":0.0001883638,"domain_scores_codex":[0.9998443,0.00002558265,0.000008761037,0.00003206904,0.00003474336,0.00005446011],"domain_scores_gemma":[0.9998863,0.00001715455,0.00002025522,0.00001681996,0.0000189003,0.00004057852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132556,0.00005559126,0.0001239765,0.00007669361,0.000006033444,0.000137921,0.00001668754,0.0001147675,0.9957622,0.0009304636,0.0001837687,0.002459361],"study_design_scores_gemma":[0.00005363176,0.0003328389,0.007310114,0.00001517034,0.00001061195,0.0006404564,0.0000637449,0.00180326,0.9846939,0.0009519758,0.004104482,0.00001991599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954276,0.01377653,0.01720091,0.0013987,0.000415261,0.0002376066,0.0006819636,0.0006852274,0.01132783],"genre_scores_gemma":[0.992463,0.001847858,0.002130307,0.000179434,0.00005567594,0.00008417389,0.0002701434,0.00002056616,0.002948832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398208,"threshold_uncertainty_score":0.004677474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204586131142632,"score_gpt":0.2795427688886821,"score_spread":0.2674969075772557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}