{"id":"W2519427975","doi":"10.1021/acsmedchemlett.5b00485","title":"Discovery of Pyrazolo[1,5-<i>a</i>]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent","year":2016,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Government of Canada; Princess Margaret Cancer Foundation","keywords":"Bioavailability; Pyrimidine; Chemistry; In vitro; Potency; Combinatorial chemistry; Pharmacokinetics; Pharmacology; Drug discovery; Solvent; Stereochemistry; Structure–activity relationship; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008946,0.0003201261,0.0004199294,0.0002738107,0.0001381946,0.0004164824,0.0003561788,0.0002378012,0.001146152],"category_scores_gemma":[0.0001173416,0.0001414985,0.000232897,0.000188662,0.0001782827,0.0003070845,0.0002353179,0.0005170073,0.0004650836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004966382,"about_ca_system_score_gemma":0.000538112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006584699,"about_ca_topic_score_gemma":0.002076572,"domain_scores_codex":[0.9999315,0.000009003605,0.000003986742,0.00001465125,0.00001953655,0.00002146215],"domain_scores_gemma":[0.9999598,0.00000413826,0.0000109886,0.000003265725,0.000008457698,0.0000133708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003545227,0.0002743354,0.0008170311,0.0002984217,0.00002689296,0.0003109891,0.00008659721,0.002113336,0.942282,0.002246766,0.0009861641,0.05020303],"study_design_scores_gemma":[0.000352346,0.004487933,0.003526565,0.00006290343,0.00007209404,0.001268542,0.00005398622,0.004961224,0.9568133,0.0005348751,0.02783178,0.00003448612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540381,0.01187447,0.01841453,0.0007055957,0.00006161071,0.0005502338,0.001285057,0.0004136456,0.01265684],"genre_scores_gemma":[0.9729151,0.008984846,0.01133977,0.0002349453,0.00003323902,0.0001572356,0.001015548,0.00003348595,0.005285764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146152,"threshold_uncertainty_score":0.003834188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046770974450791,"score_gpt":0.220324505155156,"score_spread":0.2098567954106481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}