{"id":"W2519464905","doi":"10.1016/j.bbi.2016.09.004","title":"Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice","year":2016,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"European Social Fund; Pécsi Tudományegyetem; European Commission","keywords":"Tail suspension test; Substance P; Open field; Behavioural despair test; Elevated plus maze; Anxiolytic; NK1 receptor antagonist; Internal medicine; Endocrinology; Tachykinin receptor 1; Receptor; Antagonist; Pharmacology; Receptor antagonist; Chemistry; Psychology; Neuropeptide; Medicine; Anxiety; Hippocampus; Psychiatry; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009151382,0.0001269958,0.0001655981,0.00007295715,0.0001699503,0.00003018478,0.0001401431,0.00005373299,0.00004732609],"category_scores_gemma":[0.0002343671,0.00008958692,0.00002577371,0.0001130891,0.0003000644,0.0002145467,0.0001710185,0.0001727765,0.00001413403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008661562,"about_ca_system_score_gemma":0.0000129317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343149,"about_ca_topic_score_gemma":0.00002204103,"domain_scores_codex":[0.999078,0.000167814,0.0001558739,0.0002906759,0.00006911037,0.0002385239],"domain_scores_gemma":[0.9991809,0.0005107975,0.00004548103,0.0001748073,0.00001157552,0.0000765019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001916622,0.00009356286,0.02534045,0.000004805513,5.994454e-7,0.00001621165,0.00007430833,4.809305e-8,0.9670479,0.0001378072,0.000101965,0.007163129],"study_design_scores_gemma":[0.000612737,0.0001129153,0.8080789,0.00002570719,0.000009110507,0.00006467733,0.00005527116,0.000002733214,0.1891121,0.0001213487,0.001658379,0.0001460844],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999061,0.00005143576,0.000001039362,0.0002868384,0.0001109217,0.0001338546,0.00002985049,0.00003847987,0.0002865568],"genre_scores_gemma":[0.9986755,0.0004756346,0.000009316525,0.0005069405,0.00002249665,0.00001672268,0.000001043042,0.00001385146,0.0002785408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7827385,"threshold_uncertainty_score":0.3653249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04835945949156397,"score_gpt":0.2934255206939936,"score_spread":0.2450660612024296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}