{"id":"W2519464905","doi":"10.1016/j.bbi.2016.09.004","title":"Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice","year":2016,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"European Social Fund; Pécsi Tudományegyetem; European Commission","keywords":"Tail suspension test; Substance P; Open field; Behavioural despair test; Elevated plus maze; Anxiolytic; NK1 receptor antagonist; Internal medicine; Endocrinology; Tachykinin receptor 1; Receptor; Antagonist; Pharmacology; Receptor antagonist; Chemistry; Psychology; Neuropeptide; Medicine; Anxiety; Hippocampus; Psychiatry; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605069,0.0007783849,0.0003816357,0.0008805799,0.0002169851,0.0003942216,0.0005459256,0.0004188083,0.003275745],"category_scores_gemma":[0.0001289874,0.0003272662,0.0003915639,0.0001902208,0.0006356624,0.0005603264,0.0003217293,0.001543349,0.0007709317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005468975,"about_ca_system_score_gemma":0.0003534103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006326377,"about_ca_topic_score_gemma":0.001561073,"domain_scores_codex":[0.9998069,0.00002764221,0.00001299516,0.00004837194,0.0000361587,0.00006797237],"domain_scores_gemma":[0.9996858,0.0000208809,0.0001272102,0.00002738796,0.00001374959,0.0001250793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008893851,0.000149051,0.0004360149,0.0000568125,0.00001973292,0.0000981941,0.00002707964,0.00007784026,0.9954091,0.0002440703,0.0001163451,0.002476404],"study_design_scores_gemma":[0.0001408808,0.001358605,0.01507532,0.00002350242,0.00005952386,0.0004612098,0.0001003948,0.001065268,0.9792586,0.0002996234,0.002138339,0.00001873475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895368,0.002134738,0.004250849,0.0003471613,0.00007636533,0.00003064748,0.001438865,0.0002413277,0.001943443],"genre_scores_gemma":[0.9855679,0.001952134,0.003204131,0.0001969599,0.00003251412,0.00009029789,0.001605308,0.00008732745,0.007263418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003275745,"threshold_uncertainty_score":0.01095849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04835945949156397,"score_gpt":0.2934255206939936,"score_spread":0.2450660612024296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}