{"id":"W2519569461","doi":"10.1038/cr.2016.106","title":"How to open a Ryanodine Receptor","year":2016,"lang":"en","type":"letter","venue":"Cell Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Endoplasmic reticulum; Biology; Allosteric regulation; Cell biology; Receptor; Biophysics; Ryanodine receptor 2; Muscle contraction; Contraction (grammar); Biochemistry; Anatomy; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007130854,0.000178974,0.000166624,0.0002000837,0.000152773,0.0003138474,0.0008527197,0.000757087,0.000658194],"category_scores_gemma":[0.000190398,0.0001393231,0.00008003617,0.0001875776,0.00007925629,0.000004730629,0.0008871394,0.0006007919,0.001036869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006472193,"about_ca_system_score_gemma":0.0001982587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001191082,"about_ca_topic_score_gemma":0.000003286767,"domain_scores_codex":[0.997871,0.000262417,0.0001303951,0.0006602827,0.0005094932,0.0005664219],"domain_scores_gemma":[0.998595,0.00003935372,0.00004475375,0.0006750001,0.0005121971,0.0001337166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006971011,0.000008799488,0.000002673363,0.00003136844,0.00001119195,0.000006427199,0.000008831496,3.429699e-7,0.1583372,0.000005210644,0.8373815,0.004136714],"study_design_scores_gemma":[0.0002836595,0.0002785721,0.000001932891,0.00002798502,0.000001938027,0.000001789296,0.00001548634,0.000001886833,0.1248779,0.00003595579,0.8742986,0.0001743506],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.0005293575,0.000175771,0.001026219,0.954542,0.001094862,0.0009830475,0.000087316,0.00001278163,0.04154866],"genre_scores_gemma":[0.001812042,0.000160613,0.0002312345,0.1312443,0.01840507,0.0002066316,0.001212323,0.00007650168,0.8466513],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.8232977,"threshold_uncertainty_score":0.999741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09166787142862903,"score_gpt":0.3576807101422498,"score_spread":0.2660128387136207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}