{"id":"W2519569461","doi":"10.1038/cr.2016.106","title":"How to open a Ryanodine Receptor","year":2016,"lang":"en","type":"letter","venue":"Cell Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Endoplasmic reticulum; Biology; Allosteric regulation; Cell biology; Receptor; Biophysics; Ryanodine receptor 2; Muscle contraction; Contraction (grammar); Biochemistry; Anatomy; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001994993,0.000414501,0.0006678047,0.0003195574,0.001619823,0.002012575,0.0007392766,0.01712789,0.004772177],"category_scores_gemma":[0.00967784,0.0003736467,0.0007189082,0.000156442,0.002906988,0.003302932,0.00122716,0.01910452,0.003694529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00153196,"about_ca_system_score_gemma":0.001138624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007591817,"about_ca_topic_score_gemma":0.001175257,"domain_scores_codex":[0.9990731,0.0001971894,0.0001159887,0.0001340385,0.0003531706,0.0001264587],"domain_scores_gemma":[0.9980251,0.001020262,0.0001466813,0.0001737699,0.0002464502,0.0003877897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003212468,0.00008233487,0.0005518508,0.0001314838,0.00003007727,0.003580827,0.0001102667,0.0001334051,0.003495103,0.03072354,0.9167197,0.04412017],"study_design_scores_gemma":[0.0002404022,0.0001024489,0.0004819556,0.0001011276,0.00003050207,0.003892775,0.0001716991,0.0004352005,0.002049519,0.06735744,0.9250893,0.00004766139],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001070761,0.00813574,0.000793872,0.9434881,0.04037471,0.00001180337,0.00004480518,0.00005463479,0.006025604],"genre_scores_gemma":[0.02666831,0.01203826,0.001796543,0.826662,0.1008901,0.00007356732,0.00007230297,0.00006244942,0.03173639],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01712789,"threshold_uncertainty_score":0.01596457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09166787142862903,"score_gpt":0.3576807101422498,"score_spread":0.2660128387136207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}