{"id":"W2519683881","doi":"10.15252/embj.201693889","title":"FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma","year":2016,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Institute for Molecular Bioscience, University Of Queensland; European Research Council; Svenska Läkaresällskapet; Worldwide Cancer Research; Cancerfonden; Radiumhemmets Forskningsfonder; Uppsala Universitet; Science for Life Laboratory; Vetenskapsrådet; Barncancerfonden; Uppsala Multidisciplinary Center for Advanced Computational Science; Svenska Forskningsrådet Formas; Karolinska Institutet; Johns Hopkins University; Ragnar Söderbergs stiftelse; Åke Wiberg Stiftelse","keywords":"Biology; Medulloblastoma; Malignancy; SOX9; Cancer research; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002996025,0.00007033125,0.00006847711,0.00002756073,0.0000732261,0.0000207611,0.0001038585,0.00004341988,0.00004378335],"category_scores_gemma":[0.00009666588,0.00003701219,0.00002487144,0.00004331869,0.00002966977,0.000004215403,0.00005361902,0.00005490408,0.000004465028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000186809,"about_ca_system_score_gemma":0.00005239554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008763524,"about_ca_topic_score_gemma":0.00003995206,"domain_scores_codex":[0.9994203,0.00008474709,0.0001441551,0.0001156297,0.00009909328,0.0001360818],"domain_scores_gemma":[0.999689,0.00001484397,0.00004769042,0.0001344923,0.00004421732,0.00006969224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021761,0.00001432065,0.005194796,0.000004428674,0.000005066708,0.000002077463,0.00010225,0.00007252263,0.9826214,0.00001603352,0.001273311,0.01059156],"study_design_scores_gemma":[0.002448632,0.0004890509,0.02698843,0.0005284972,0.00002180447,0.0004471727,0.000209896,0.000332737,0.959289,0.001552204,0.007376827,0.0003157936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958579,0.0004583482,0.002310934,0.001050037,0.00009550873,0.0000639461,0.000003691703,0.000003701085,0.0001559503],"genre_scores_gemma":[0.9989052,0.000284774,0.0001955047,0.0002060979,0.0001898009,0.00000417083,0.000001795741,0.000009923229,0.0002027006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02333251,"threshold_uncertainty_score":0.1509313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007597667250437105,"score_gpt":0.250410376727126,"score_spread":0.2428127094766888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}