{"id":"W2519683881","doi":"10.15252/embj.201693889","title":"FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma","year":2016,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Institute for Molecular Bioscience, University Of Queensland; European Research Council; Svenska Läkaresällskapet; Worldwide Cancer Research; Cancerfonden; Radiumhemmets Forskningsfonder; Uppsala Universitet; Science for Life Laboratory; Vetenskapsrådet; Barncancerfonden; Uppsala Multidisciplinary Center for Advanced Computational Science; Svenska Forskningsrådet Formas; Karolinska Institutet; Johns Hopkins University; Ragnar Söderbergs stiftelse; Åke Wiberg Stiftelse","keywords":"Biology; Medulloblastoma; Malignancy; SOX9; Cancer research; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008096671,0.0002784573,0.0002382137,0.0003469905,0.0001604035,0.0002368422,0.000170778,0.0002132874,0.001479254],"category_scores_gemma":[0.00008213576,0.0001618949,0.0002186024,0.0001496486,0.0002315764,0.00008116182,0.0001529958,0.0004011102,0.0003538206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004287,"about_ca_system_score_gemma":0.0001946004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001790853,"about_ca_topic_score_gemma":0.002310515,"domain_scores_codex":[0.9999069,0.00001394799,0.00001256185,0.00001685429,0.00002887869,0.00002095974],"domain_scores_gemma":[0.9998796,0.00002157054,0.00003468373,0.00001172547,0.000007443796,0.00004500393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005715556,0.00001629343,0.0001753896,0.000007358574,0.000004414455,0.00006889321,0.000004867966,0.00002996381,0.9992542,0.00003698432,0.0000224814,0.000322],"study_design_scores_gemma":[0.00001321121,0.0001715138,0.0060083,0.000002851605,0.00001586389,0.0004052919,0.00002206356,0.0008809513,0.9913092,0.00003184863,0.001136473,0.00000247752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975408,0.0005407078,0.0009342579,0.00004996108,0.00002105695,0.00001193567,0.0002744732,0.00009457044,0.0005321673],"genre_scores_gemma":[0.9976252,0.0002790474,0.0004443712,0.00001160143,0.000003795844,0.000009828671,0.000227151,0.00001732918,0.001381663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001790853,"threshold_uncertainty_score":0.004948616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007597667250437105,"score_gpt":0.250410376727126,"score_spread":0.2428127094766888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}