{"id":"W2519711882","doi":"10.1002/cpt.509","title":"Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need","year":2016,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Biomedical and Engineering Education","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Alfred P. Sloan Foundation; Ewing Marion Kauffman Foundation","keywords":"Process management; Pace; Knowledge management; Business; Business process reengineering; Structuring; Maturity (psychological); Sustainability; Process (computing); Product (mathematics); Risk analysis (engineering); New product development; Computer science; Marketing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02081124,0.000938995,0.0006050242,0.002403116,0.00402163,0.01327619,0.002888084,0.006886692,0.005594886],"category_scores_gemma":[0.01697764,0.0003146074,0.001164416,0.001902532,0.01283199,0.01316364,0.01425382,0.004147985,0.001799399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004884416,"about_ca_system_score_gemma":0.01866344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001785556,"about_ca_topic_score_gemma":0.001738698,"domain_scores_codex":[0.9877989,0.005956243,0.0007081235,0.001582046,0.002561367,0.001393229],"domain_scores_gemma":[0.9881875,0.004567805,0.001889605,0.001492894,0.001580132,0.002281935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001256015,0.0004980839,0.01631855,0.001499484,0.0002720015,0.0007868479,0.009849801,0.01198838,0.00920018,0.6185599,0.02591848,0.3049826],"study_design_scores_gemma":[0.00008241764,0.0008185777,0.006683958,0.001187486,0.0001609074,0.0009180185,0.009278974,0.01246014,0.003677431,0.6625085,0.3020229,0.0002007052],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1196122,0.01178106,0.4315586,0.2330894,0.002672727,0.001267075,0.0002917238,0.001265625,0.1984615],"genre_scores_gemma":[0.7682388,0.008114628,0.1909999,0.02115952,0.001204494,0.000690653,0.000279789,0.0002019907,0.009110224],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02081124,"threshold_uncertainty_score":0.1100617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0361001060161819,"score_gpt":0.3540033637124315,"score_spread":0.3179032576962496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}