{"id":"W2519711882","doi":"10.1002/cpt.509","title":"Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need","year":2016,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Biomedical and Engineering Education","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Alfred P. Sloan Foundation; Ewing Marion Kauffman Foundation","keywords":"Process management; Pace; Knowledge management; Business; Business process reengineering; Structuring; Maturity (psychological); Sustainability; Process (computing); Product (mathematics); Risk analysis (engineering); New product development; Computer science; Marketing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004060383,0.000189769,0.0003140833,0.0002050896,0.0000306783,0.00001222201,0.0001878185,0.0002252696,0.00001484496],"category_scores_gemma":[0.0000921595,0.0001448117,0.00003002597,0.0009496462,0.00006033698,0.00008098999,0.00008339046,0.0002157879,0.00004550752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003521083,"about_ca_system_score_gemma":0.0000982226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002522895,"about_ca_topic_score_gemma":0.000006507435,"domain_scores_codex":[0.998413,0.00005736248,0.0006525811,0.0002813861,0.0001858218,0.0004098593],"domain_scores_gemma":[0.9991176,0.0001973829,0.00004164005,0.0001171404,0.000139596,0.0003866255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0007397372,0.0007474193,0.2484977,0.0007144123,0.0009190465,0.00007111836,0.001845919,0.0008619847,0.0124577,0.0005542499,0.2308051,0.5017856],"study_design_scores_gemma":[0.0100137,0.001716605,0.8775156,0.0009824596,0.0003334278,0.00002022309,0.001552792,0.02451903,0.0005244188,0.0003412579,0.08134029,0.001140206],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.942009,0.0002049791,0.02581736,0.02604714,0.00508606,0.0004534967,0.00001246695,0.0002669804,0.000102551],"genre_scores_gemma":[0.991044,0.00007536167,0.001243669,0.006490401,0.001041609,0.00002005402,0.000004333506,0.00002483863,0.00005577287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6290179,"threshold_uncertainty_score":0.5905249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0361001060161819,"score_gpt":0.3540033637124315,"score_spread":0.3179032576962496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}