{"id":"W2519745468","doi":"10.1080/15384101.2016.1231287","title":"Cancer cells that survive checkpoint adaptation contain micronuclei that harbor damaged DNA","year":2016,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Alberta Innovates; University of Lethbridge","keywords":"Micronucleus test; Biology; Chromothripsis; G2-M DNA damage checkpoint; DNA damage; Nocodazole; Mitosis; Cisplatin; Cell biology; Genome instability; Molecular biology; Cancer research; Cell cycle; Genetics; Cell cycle checkpoint; Cancer; DNA; Chemistry; Cell; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513959,0.0002962513,0.0003212016,0.0002496968,0.0001709603,0.0002344184,0.0001177954,0.0002454011,0.0008761566],"category_scores_gemma":[0.0001762756,0.0001027998,0.0001290924,0.0002383696,0.000126618,0.0001754112,0.0001797904,0.0002858284,0.000282706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002295187,"about_ca_system_score_gemma":0.0001725201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001316721,"about_ca_topic_score_gemma":0.002092905,"domain_scores_codex":[0.9998783,0.0000138627,0.00001563649,0.00003344346,0.00003683176,0.00002188992],"domain_scores_gemma":[0.9997813,0.00003933024,0.000071247,0.00002784661,0.00004606075,0.00003429381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067961,0.00001954795,0.00317446,0.00005947907,0.00001259445,0.00007364014,0.00002977789,0.00005681944,0.9936109,0.00005760128,0.00002693651,0.002771488],"study_design_scores_gemma":[0.000009201602,0.0007376612,0.08688902,0.0000105149,0.00002646261,0.0009993924,0.00006025261,0.0004308938,0.906864,0.0001040542,0.003859629,0.000008878518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862674,0.00680469,0.004589846,0.00003754174,0.00002005654,0.00007314903,0.0007166303,0.00009909927,0.001391418],"genre_scores_gemma":[0.9929329,0.001533771,0.002836969,0.00003854495,0.000003963557,0.00004627096,0.0006650201,0.00001315143,0.001929554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316721,"threshold_uncertainty_score":0.002931058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135841528475733,"score_gpt":0.2222010441670723,"score_spread":0.208616891319499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}