{"id":"W2519745468","doi":"10.1080/15384101.2016.1231287","title":"Cancer cells that survive checkpoint adaptation contain micronuclei that harbor damaged DNA","year":2016,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Alberta Innovates; University of Lethbridge","keywords":"Micronucleus test; Biology; Chromothripsis; G2-M DNA damage checkpoint; DNA damage; Nocodazole; Mitosis; Cisplatin; Cell biology; Genome instability; Molecular biology; Cancer research; Cell cycle; Genetics; Cell cycle checkpoint; Cancer; DNA; Chemistry; Cell; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935511,0.0001906279,0.0001512242,0.00002910134,0.00007125121,0.00002608216,0.0002192075,0.0001612724,0.0002606456],"category_scores_gemma":[0.00001579581,0.0001515468,0.0001100985,0.00003814338,0.00006293325,0.00001004189,0.0001137551,0.00005999343,0.0001198539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005183271,"about_ca_system_score_gemma":0.00007127021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001532811,"about_ca_topic_score_gemma":0.0001691298,"domain_scores_codex":[0.9988666,0.00009221927,0.0001444468,0.000433542,0.0001419958,0.0003212168],"domain_scores_gemma":[0.999261,0.00001874915,0.0001221813,0.0004294458,0.00005812482,0.0001104912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006335702,0.00004485894,0.0005150568,0.00001365978,0.00002527831,0.000004521796,0.0000916638,0.00001259037,0.9963304,0.00002326739,0.001089446,0.001785832],"study_design_scores_gemma":[0.0008967937,0.00009972593,0.00181757,0.00002262441,0.00002061963,0.000001046609,0.0001937762,0.00006154279,0.986568,0.00007278229,0.009998423,0.0002471264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993117,0.0004235815,0.003770608,0.0002246381,0.0004105956,0.0002594162,0.00007053196,0.00003983022,0.001683739],"genre_scores_gemma":[0.9941236,0.0003178805,0.0007758545,0.0002679334,0.000134572,0.00004539955,0.00002804074,0.00004976503,0.004256917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009762499,"threshold_uncertainty_score":0.6179898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135841528475733,"score_gpt":0.2222010441670723,"score_spread":0.208616891319499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}