{"id":"W2519881587","doi":"10.1371/journal.pone.0162902","title":"Stop Codon Polymorphisms in the Human SLC9A1 Gene Disrupt or Compromise Na+/H+ Exchanger Function","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Mutant; Amino acid; Stop codon; Biology; Cytosol; Start codon; Intracellular pH; Mutant protein; Sodium–hydrogen antiporter; Gene; Molecular biology; Intracellular; Biochemistry; Cell biology; Chemistry; Sodium; Messenger RNA; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012126,0.000555274,0.0004050228,0.0002115464,0.0001764463,0.0002367074,0.000239481,0.0006163186,0.001830811],"category_scores_gemma":[0.0002336853,0.0002391247,0.0004796617,0.0002126847,0.0003613352,0.00011423,0.0002189169,0.0006140153,0.0008832432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000283021,"about_ca_system_score_gemma":0.0002954587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009401333,"about_ca_topic_score_gemma":0.001367485,"domain_scores_codex":[0.9997661,0.00004752383,0.00004817734,0.00005460687,0.0000513307,0.00003233283],"domain_scores_gemma":[0.9997537,0.00007299844,0.00008247561,0.00003097434,0.0000141821,0.00004577239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002336101,0.00004555095,0.0005545739,0.00003932756,0.00002579905,0.0005570116,0.00002353863,0.0001502623,0.9964247,0.0002085987,0.00008810204,0.001648803],"study_design_scores_gemma":[0.0001426592,0.0008208739,0.01654889,0.00002663203,0.0001507639,0.005585338,0.00006979272,0.003313297,0.9616271,0.0002729414,0.01140739,0.00003439797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928437,0.0006440679,0.004685373,0.0001511165,0.00007970231,0.0000667169,0.0006053393,0.0001442287,0.0007796839],"genre_scores_gemma":[0.9914349,0.0004199506,0.005281561,0.000156417,0.0000192564,0.00004268469,0.0007672455,0.0001021405,0.00177584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001830811,"threshold_uncertainty_score":0.006124675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04538876424521846,"score_gpt":0.2350521796031755,"score_spread":0.189663415357957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}