{"id":"W2519908811","doi":"10.1200/jco.2012.30.15_suppl.3578","title":"The role of TP, TS, and DPD as potential predictors of outcome following capecitabine plus oxaliplatin (XELOX) versus bolus 5-fluorouracil/leucovorin (5-FU/LV) as adjuvant therapy for stage III colon cancer: Biomarker findings from study NO16968 (XELOXA).","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"","keywords":"Medicine; Capecitabine; Oxaliplatin; Internal medicine; Dihydropyrimidine dehydrogenase; Colorectal cancer; Fluorouracil; Thymidine phosphorylase; Oncology; Thymidylate synthase; Population; Clinical endpoint; Gastroenterology; Cancer; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001294359,0.0002827001,0.0004574977,0.0002002035,0.0001114685,0.0003585913,0.0002033447,0.0003345888,0.0006130455],"category_scores_gemma":[0.001517923,0.0001376749,0.0004140855,0.0002722,0.0001864909,0.0002801175,0.0002106106,0.0004741738,0.00009219728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791984,"about_ca_system_score_gemma":0.0002781895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004661263,"about_ca_topic_score_gemma":0.001016099,"domain_scores_codex":[0.9997044,0.0001496411,0.00002383942,0.00004890086,0.00003808,0.00003506308],"domain_scores_gemma":[0.9988824,0.0003814582,0.0004598001,0.00003952493,0.00004085089,0.0001961217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1359321,0.00114041,0.8225092,0.0001980528,0.001030834,0.000215786,0.0001536629,0.0006294277,0.01155169,0.00004657776,0.0002465663,0.02634566],"study_design_scores_gemma":[0.003374979,0.0405979,0.9500244,0.0000276336,0.0008710757,0.0004638045,0.0001038186,0.001243488,0.002404676,0.0000804817,0.0007909039,0.00001674339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994766,0.0003477692,0.000030244,0.00002080121,0.000003406589,0.00001065662,0.00005934977,6.543983e-7,0.00005052725],"genre_scores_gemma":[0.9996521,0.00007340253,0.00006698959,0.00001655426,0.000007133396,0.00001078163,0.000113845,4.684086e-7,0.00005870881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294359,"threshold_uncertainty_score":0.006845295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09166070058760821,"score_gpt":0.4548548718735047,"score_spread":0.3631941712858964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}