{"id":"W2520119998","doi":"10.1016/j.chom.2016.08.006","title":"Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction","year":2016,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Fogarty International Center; National Institutes of Health; Wellcome Trust","keywords":"Biology; Virology; Glycoprotein; Virus; Transmembrane protein; Viral envelope; Co-receptor; Interferon; Viral entry; Human immunodeficiency virus (HIV); Viral replication; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001191229,0.0001583059,0.0002244308,0.000151587,0.00009899721,0.000006561881,0.0001949195,0.0001643298,0.0009427078],"category_scores_gemma":[0.0000503009,0.0001090503,0.0000883233,0.0002441899,0.000152752,0.00005618349,0.00003849943,0.0001115987,0.007645424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009515979,"about_ca_system_score_gemma":0.00009142728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005256496,"about_ca_topic_score_gemma":0.00007650254,"domain_scores_codex":[0.9988062,0.0001313622,0.0002645812,0.0003183265,0.00004462824,0.0004349202],"domain_scores_gemma":[0.9992194,0.0002031537,0.00006844034,0.0003405209,0.0001074283,0.00006112675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003867416,0.0001973355,0.001432607,0.00002221759,0.00007123016,0.000009874471,0.0002053373,1.065096e-7,0.9472339,0.00006954293,0.04970817,0.0006629213],"study_design_scores_gemma":[0.002387827,0.0001892657,0.01354557,0.00006265772,0.00002267686,0.000004136272,0.00005613076,2.342756e-8,0.714758,0.00003960939,0.2688026,0.0001314766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866288,0.002780533,0.001799051,0.001821043,0.000293217,0.0005290377,0.0007364978,0.00008087073,0.005330931],"genre_scores_gemma":[0.9668392,0.0004039489,0.000190066,0.00009017575,0.00001641348,0.00003289153,0.0001927576,0.00001996029,0.0322146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2324759,"threshold_uncertainty_score":0.9999706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008883410551628,"score_gpt":0.2305799876093677,"score_spread":0.2204911535038514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}