{"id":"W2520135608","doi":"10.1074/jbc.m116.753327","title":"Structural Analysis and Inhibition of TraE from the pKM101 Type IV Secretion System","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Plasmid; Complementation; Chemistry; Secretion; Agrobacterium tumefaciens; Heterologous; Agrobacterium; Cell biology; Molecular biology; Biology; Biochemistry; DNA; Phenotype; Transgene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412774,0.000331779,0.0002865999,0.0001747572,0.0001560143,0.0002027486,0.0003944286,0.0003253924,0.000605709],"category_scores_gemma":[0.0001668689,0.0001533553,0.0002864633,0.0001920306,0.0001543097,0.0001206192,0.0001301123,0.0006528859,0.0002329286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004447005,"about_ca_system_score_gemma":0.0002071028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00122356,"about_ca_topic_score_gemma":0.00150486,"domain_scores_codex":[0.9998387,0.00002536275,0.00001865337,0.00001802331,0.00007081389,0.00002838016],"domain_scores_gemma":[0.9999162,0.00002366684,0.00002198418,0.000007553922,0.00001172212,0.00001890839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001032075,0.00009150799,0.000138057,0.00007187841,0.00001207883,0.0000785354,0.00001163644,0.0005965757,0.9975469,0.00007646676,0.00005633866,0.001216793],"study_design_scores_gemma":[0.00003467656,0.000429665,0.00236687,0.000007050642,0.00001645193,0.0002001398,0.00001699082,0.00318987,0.9918685,0.00001336309,0.001849334,0.000007059894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953262,0.001891766,0.0007928574,0.0001136569,0.00002378013,0.00002870672,0.0003303517,0.00003671667,0.001456056],"genre_scores_gemma":[0.9949438,0.001086785,0.001205084,0.00006209369,0.000004411199,0.00002867127,0.001019662,0.00001452803,0.001635009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122356,"threshold_uncertainty_score":0.003226519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066790286690451,"score_gpt":0.2150798811338457,"score_spread":0.2044119782669412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}