{"id":"W2520209744","doi":"10.1016/j.ebiom.2016.09.004","title":"Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins","year":2016,"lang":"en","type":"article","venue":"EBioMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Clinical Research Institute; Université de Montréal; McGill University; Fowler Kennedy Sport Medicine Clinic; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; National Institutes of Health; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Epitope; Antibody-dependent cell-mediated cytotoxicity; Glycoprotein; Antibody; Virology; Receptor; Human immunodeficiency virus (HIV); Biology; Computational biology; Immunology; Genetics; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003949243,0.0003237108,0.0005219469,0.0004551856,0.0002882709,0.00002110025,0.0002605074,0.0001918416,0.004581742],"category_scores_gemma":[0.0003172451,0.000187415,0.00008613087,0.0002714875,0.0004664735,0.0000846082,0.0001144707,0.0001902399,0.08646788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300719,"about_ca_system_score_gemma":0.0001018902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001162643,"about_ca_topic_score_gemma":0.00002277898,"domain_scores_codex":[0.9979216,0.0002151987,0.0003757433,0.0005133333,0.000134992,0.0008391282],"domain_scores_gemma":[0.9987695,0.0003954979,0.0000928827,0.000469487,0.0001044663,0.0001681587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005032049,0.0002460836,0.01098409,0.00002743157,0.0002509086,0.00006433758,0.0005322013,1.582378e-7,0.8070118,0.00001687916,0.1726552,0.007707762],"study_design_scores_gemma":[0.004909447,0.001562441,0.003891969,0.0003850708,0.00002894105,0.00003080228,0.0001266638,1.502391e-7,0.5237458,0.000005077927,0.4650974,0.0002162191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812852,0.001141758,0.0002268871,0.01226979,0.0005992723,0.0008979489,0.001863172,0.0001230468,0.001592953],"genre_scores_gemma":[0.9538044,0.000455841,0.000438298,0.0008166824,0.0001842494,0.00009453043,0.001339846,0.00004031647,0.04282586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2924422,"threshold_uncertainty_score":0.9963282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883856834220371,"score_gpt":0.2787038753360949,"score_spread":0.2598653069938912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}