{"id":"W2520228482","doi":"10.1101/gr.193649.115","title":"Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia","year":2016,"lang":"en","type":"article","venue":"Genome Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Lastentautien Tutkimussäätiö; Vetenskapsrådet; Jane ja Aatos Erkon Säätiö; Tays; Suomen Kulttuurirahasto; Academy of Finland; Cancerfonden; Svenska Forskningsrådet Formas","keywords":"Biology; Enhancer; RUNX1; ETV6; Fusion gene; Gene; Genetics; Psychological repression; Genome; Regulation of gene expression; Transcription factor; Gene expression; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003646707,0.0002398309,0.0005036219,0.0005263889,0.0002277485,0.00003554478,0.0006303901,0.0002683947,0.0005453656],"category_scores_gemma":[0.001094679,0.0001290916,0.00008766338,0.0009002848,0.0008884963,0.0001347128,0.001156031,0.0007720736,0.0001516151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002038093,"about_ca_system_score_gemma":0.001476454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004977083,"about_ca_topic_score_gemma":0.00001499639,"domain_scores_codex":[0.9950656,0.0005341282,0.0005779671,0.0007435791,0.00191011,0.001168634],"domain_scores_gemma":[0.9966066,0.001242267,0.0001075166,0.00114533,0.0004751016,0.0004231816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001166594,0.0001002885,0.01957815,0.0001293862,0.0001093545,0.0002620693,0.0006753297,0.000006933382,0.9639627,0.00002635849,0.005635212,0.008347683],"study_design_scores_gemma":[0.01821999,0.002198632,0.6201273,0.0007069943,0.00009890165,0.0005387019,0.0008730066,0.001177111,0.2582812,0.002144598,0.09490915,0.0007244518],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864251,0.00320811,0.0007302263,0.005776937,0.00003506274,0.001185352,0.00008561813,0.00002910965,0.002524493],"genre_scores_gemma":[0.9815302,0.006215823,0.0006970119,0.0001387131,0.0001653843,0.0001030651,0.00005735703,0.00006858153,0.0110239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7056814,"threshold_uncertainty_score":0.5971371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864064239040007,"score_gpt":0.3293125841165261,"score_spread":0.300671941726126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}