{"id":"W2520340383","doi":"10.1038/ncomms12700","title":"The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Jewish General Hospital; McGill University Health Centre; Institut universitaire de cardiologie et de pneumologie de Québec; Hôtel-Dieu de Québec; McGill University; Montreal Neurological Institute and Hospital; Université Laval; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Versus Arthritis; Ministero dello Sviluppo Economico; Rosetrees Trust; Bayer HealthCare; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; National Institute for Health and Care Research; Genome Canada; McGill University; GlaxoSmithKline; Pfizer; Terry Fox Foundation; Eli Lilly and Company","keywords":"PI3K/AKT/mTOR pathway; IDH1; Isocitrate dehydrogenase; mTORC1; Citric acid cycle; Protein kinase B; Chemistry; Cancer research; RPTOR; Biology; Cell biology; Biochemistry; Mutant; Signal transduction; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006688221,0.000364795,0.0001622754,0.0002779252,0.000159838,0.0003229349,0.0001311761,0.0001919608,0.001679254],"category_scores_gemma":[0.00008304881,0.0001190931,0.0002153917,0.0001335121,0.0001504375,0.0001675918,0.0003537443,0.0002525742,0.0005595077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003617457,"about_ca_system_score_gemma":0.0001965058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003859822,"about_ca_topic_score_gemma":0.0008094064,"domain_scores_codex":[0.9999088,0.00001382326,0.000005350469,0.00002300004,0.0000271321,0.00002177366],"domain_scores_gemma":[0.9999603,0.000004572738,0.0000139136,0.000003764306,0.000006131401,0.00001132098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000177952,0.00001566207,0.0005521192,0.00008463394,0.00001285566,0.0001440022,0.00001213095,0.000168019,0.9921831,0.0005067434,0.0002419228,0.005900735],"study_design_scores_gemma":[0.00003962162,0.0002723151,0.015607,0.00002000195,0.00002458521,0.0007110161,0.00004030519,0.001875982,0.965353,0.0005759593,0.01547011,0.00001023983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641157,0.01585233,0.006213245,0.0006376245,0.0001862593,0.00004865171,0.000898937,0.0005418048,0.01150531],"genre_scores_gemma":[0.9902062,0.003722333,0.001480763,0.0001266643,0.00003333235,0.00002372418,0.0004837497,0.00002124437,0.003902042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679254,"threshold_uncertainty_score":0.005617619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146164350274076,"score_gpt":0.2824826673253686,"score_spread":0.267866232297961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}