{"id":"W2520375473","doi":"10.1016/j.stemcr.2016.08.003","title":"Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation","year":2016,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Hebrew University of Jerusalem; Rosetrees Trust","keywords":"Biology; RUNX1; Embryonic stem cell; Chromosome 21; Neural stem cell; Downregulation and upregulation; Cell biology; Genetics; Phenotype; Progenitor cell; Neural development; Stem cell; Gene; Transcription factor; Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009346027,0.0002151122,0.0001380981,0.0002729459,0.000124005,0.0002751957,0.0001495633,0.000135704,0.001072592],"category_scores_gemma":[0.0001335407,0.00008368647,0.0001664111,0.0001246585,0.0001815915,0.0001416963,0.0001660299,0.0003104939,0.0003354403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927024,"about_ca_system_score_gemma":0.0001454606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007609635,"about_ca_topic_score_gemma":0.001051096,"domain_scores_codex":[0.9999341,0.00000548484,0.00001057419,0.00001493594,0.00002566515,0.000009307133],"domain_scores_gemma":[0.9999202,0.00002018362,0.00001673889,0.00001144253,0.00001172762,0.00001969305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002526039,0.000004677884,0.001034339,0.00001055052,0.000002685824,0.0001314053,0.00001652182,0.00003329561,0.9976628,0.0001801305,0.00001050094,0.0008878728],"study_design_scores_gemma":[0.00001046251,0.00009609406,0.02665988,0.000006802522,0.00003002974,0.001344552,0.00006879713,0.0009482176,0.9648988,0.0001470356,0.005784102,0.000005157251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928022,0.0008635123,0.003863544,0.00006699241,0.00001231526,0.00001928819,0.0009008046,0.00002979934,0.001441541],"genre_scores_gemma":[0.9901119,0.0009312955,0.003402933,0.00003797171,0.00000507513,0.00002221992,0.002345364,0.00002424812,0.003118967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072592,"threshold_uncertainty_score":0.00358814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767270901193901,"score_gpt":0.2617857941754666,"score_spread":0.2441130851635276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}