{"id":"W2520412885","doi":"10.1093/glycob/cww096","title":"Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from<i>Bacteroides thetaiotaomicron</i>(BT4657)","year":2016,"lang":"en","type":"article","venue":"Glycobiology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Calgary; University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; National Institutes of Health; University of Saskatchewan; Canadian Light Source","keywords":"Bacteroides thetaiotaomicron; Biochemistry; Chemistry; Glucuronic acid; Iduronic acid; Peptide sequence; Glycosaminoglycan; Uronic acid; Heparan sulfate; Extracellular matrix; Polysaccharide; Biology; Stereochemistry; Bacteria; Gene; Genetics; Bacteroides","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007604865,0.0002054985,0.0001889968,0.0001262446,0.00007054267,0.0002238304,0.0001827673,0.0001664819,0.0008074798],"category_scores_gemma":[0.0001388653,0.000107122,0.0002506237,0.0002213031,0.0001203172,0.0001162983,0.00009722799,0.0002286998,0.0002103346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490617,"about_ca_system_score_gemma":0.0001159642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002211706,"about_ca_topic_score_gemma":0.001189968,"domain_scores_codex":[0.999945,0.000006411213,0.000004017923,0.00001696129,0.00001339087,0.00001420103],"domain_scores_gemma":[0.9999199,0.000009735708,0.00002177108,0.000004971171,0.00001405126,0.00002957437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004672154,0.00002836413,0.00587057,0.00005784052,0.00001843674,0.0001675898,0.00008069175,0.0003255272,0.9899941,0.00007158499,0.00009757634,0.00282051],"study_design_scores_gemma":[0.0001127288,0.0009269872,0.3702517,0.00004170887,0.00009464308,0.002925379,0.0003843352,0.01017405,0.6067067,0.0002170327,0.008099699,0.00006503327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983261,0.0006234142,0.0004196748,0.00003063651,0.000003438682,0.000003932641,0.0001785386,0.000008479476,0.0004056955],"genre_scores_gemma":[0.9976706,0.0002953582,0.0004951794,0.00002308214,0.000004011263,0.000004448651,0.001013739,0.000005584809,0.0004879172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002211706,"threshold_uncertainty_score":0.004397631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505499476746068,"score_gpt":0.2532905103772626,"score_spread":0.238235515609802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}