{"id":"W2520412885","doi":"10.1093/glycob/cww096","title":"Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from<i>Bacteroides thetaiotaomicron</i>(BT4657)","year":2016,"lang":"en","type":"article","venue":"Glycobiology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Calgary; University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; National Institutes of Health; University of Saskatchewan; Canadian Light Source","keywords":"Bacteroides thetaiotaomicron; Biochemistry; Chemistry; Glucuronic acid; Iduronic acid; Peptide sequence; Glycosaminoglycan; Uronic acid; Heparan sulfate; Extracellular matrix; Polysaccharide; Biology; Stereochemistry; Bacteria; Gene; Genetics; Bacteroides","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002451301,0.000230136,0.0004176103,0.00006790317,0.00005737637,0.00001016975,0.0003191898,0.0003007676,0.0001443942],"category_scores_gemma":[0.00009968924,0.000158841,0.0001044546,0.00007374548,0.0008409267,0.00001473961,0.0002560829,0.0001152658,0.000003717837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002136234,"about_ca_system_score_gemma":0.0001706916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006662296,"about_ca_topic_score_gemma":0.0003384483,"domain_scores_codex":[0.9983776,0.0001435506,0.0005337246,0.0004671065,0.0001282972,0.0003496721],"domain_scores_gemma":[0.9988059,0.00008946372,0.000246032,0.0005344778,0.000214396,0.000109663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00126556,0.00006259732,0.03499937,0.00003445741,0.0001012961,0.000002095629,0.00004345113,0.000003431466,0.9581316,0.000513988,0.0001676519,0.004674572],"study_design_scores_gemma":[0.001650761,0.0005443808,0.112244,0.00002473881,0.00001605799,0.00001980197,0.00007466667,0.0000163837,0.8795927,0.001192261,0.00442467,0.00019965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956735,0.0008113577,0.0005050476,0.00008101709,0.0001099198,0.0003053144,0.002042842,0.000008144835,0.0004628276],"genre_scores_gemma":[0.9983557,0.0005292729,0.0004813734,0.0000529584,0.0001039099,0.00001247549,0.0003209258,0.00001294134,0.0001303778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07853886,"threshold_uncertainty_score":0.6477348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505499476746068,"score_gpt":0.2532905103772626,"score_spread":0.238235515609802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}