{"id":"W2520427452","doi":"10.1111/cpr.12291","title":"p53‐dependent up‐regulation of <i><scp>CDKN</scp>1A</i> and down‐regulation of <i><scp>CCNE</scp>2</i> in response to beryllium","year":2016,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"Sarcoidosis and Beryllium Toxicity Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Army Research Office; National Center for Research Resources; National Institutes of Health; University of Nevada, Las Vegas","keywords":"Cyclin B1; Cell cycle; Gene knockdown; Cyclin; Messenger RNA; Molecular biology; Cyclin A; Biology; Cycloheximide; Cyclin D; Cell biology; Chemistry; Cell; Protein biosynthesis; Biochemistry; Apoptosis; Gene; Cyclin-dependent kinase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001965355,0.0002890715,0.0005764095,0.0007166206,0.00009086152,0.00004673844,0.0001476499,0.0003040629,0.00004075703],"category_scores_gemma":[0.001303636,0.0002286041,0.0001159321,0.000690684,0.0001411524,0.0003919515,0.0001146112,0.0001989787,0.00004455923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747864,"about_ca_system_score_gemma":0.0002455461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007385656,"about_ca_topic_score_gemma":0.00007711682,"domain_scores_codex":[0.9965827,0.0004125877,0.0009464807,0.0005880191,0.001000113,0.0004700338],"domain_scores_gemma":[0.9974095,0.0008977897,0.0003279837,0.0005440791,0.0005543468,0.0002663508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006171098,0.0003539266,0.05542227,0.0002327336,0.0000240579,0.000002454233,0.001238203,0.00009719784,0.935896,0.00008556952,0.001912293,0.004118175],"study_design_scores_gemma":[0.002744821,0.0007657025,0.2230802,0.0003315753,0.00005058034,0.00001316052,0.000199128,0.0006928988,0.7707208,0.0002334101,0.001108082,0.00005961823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935474,0.0003198719,0.001814894,0.0008980757,0.0001548293,0.001565011,0.00003585415,0.00004282728,0.00162126],"genre_scores_gemma":[0.9910647,0.0001080033,0.0004934891,0.0002112476,0.0001940438,0.00009698208,0.00006999601,0.00004585798,0.007715628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.167658,"threshold_uncertainty_score":0.9322206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844253059550878,"score_gpt":0.2702656010923699,"score_spread":0.2518230704968611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}