{"id":"W2520427452","doi":"10.1111/cpr.12291","title":"p53‐dependent up‐regulation of <i><scp>CDKN</scp>1A</i> and down‐regulation of <i><scp>CCNE</scp>2</i> in response to beryllium","year":2016,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"Sarcoidosis and Beryllium Toxicity Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Army Research Office; National Center for Research Resources; National Institutes of Health; University of Nevada, Las Vegas","keywords":"Cyclin B1; Cell cycle; Gene knockdown; Cyclin; Messenger RNA; Molecular biology; Cyclin A; Biology; Cycloheximide; Cyclin D; Cell biology; Chemistry; Cell; Protein biosynthesis; Biochemistry; Apoptosis; Gene; Cyclin-dependent kinase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007945533,0.0004528491,0.0002193761,0.0002441062,0.0001514888,0.0002569033,0.0001548832,0.0001966075,0.00282843],"category_scores_gemma":[0.0001047099,0.0001409094,0.0002982799,0.000182019,0.0003158636,0.0001840915,0.000150504,0.00049811,0.0005673349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000384474,"about_ca_system_score_gemma":0.0002773971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000118,"about_ca_topic_score_gemma":0.001316271,"domain_scores_codex":[0.9998788,0.00001109135,0.00001305747,0.00003330165,0.00003039878,0.00003328528],"domain_scores_gemma":[0.9998623,0.00001907648,0.00004222014,0.00001811127,0.00001702524,0.0000412969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008035566,0.00001311666,0.00007497211,0.00002751796,0.000002245542,0.00002811971,0.000004627996,0.00001856313,0.9992942,0.00002907141,0.00003435486,0.000392762],"study_design_scores_gemma":[0.000007538418,0.00007592708,0.002719416,0.000002056224,0.000004239967,0.0001033289,0.000007383487,0.0001389989,0.9959586,0.00001116405,0.0009698315,0.00000160485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914949,0.002107657,0.001704341,0.000145696,0.00006840951,0.00005070892,0.0009947072,0.0002045699,0.003229084],"genre_scores_gemma":[0.9926376,0.0007957933,0.001123987,0.00005129497,0.00001024257,0.00005438737,0.001033913,0.00005046462,0.004242218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00282843,"threshold_uncertainty_score":0.009461999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844253059550878,"score_gpt":0.2702656010923699,"score_spread":0.2518230704968611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}