{"id":"W2520565432","doi":"10.1021/es303289n","title":"Accumulation and Biotransformation of BDE-47 by Zebrafish Larvae and Teratogenicity and Expression of Genes along the Hypothalamus–Pituitary–Thyroid Axis","year":2012,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Biotransformation; Hypothalamus; Zebrafish; Hypothalamic–pituitary–thyroid axis; Thyroid; Pituitary gland; Endocrinology; Biology; Internal medicine; Larva; Gene; Chemistry; Thyroid hormones; Medicine; Genetics; Ecology; Biochemistry; Hormone; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000362088,0.00008423168,0.0001424589,0.0001383085,0.0001827661,0.000005155107,0.00007177128,0.0001028455,0.00001444049],"category_scores_gemma":[0.00001515599,0.00005913169,0.00001022549,0.0001682139,0.001279442,0.000304074,0.00009658545,0.00009293441,7.867184e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000365747,"about_ca_system_score_gemma":0.00001732253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003145635,"about_ca_topic_score_gemma":0.00000579459,"domain_scores_codex":[0.9992252,0.00001563555,0.0002057845,0.0001654779,0.0001862218,0.0002016585],"domain_scores_gemma":[0.9996806,0.0000177897,0.00009751563,0.0001251713,0.000005317783,0.00007354483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008533587,0.0000331435,0.363024,0.00001961101,0.000002053946,1.057849e-7,0.0005385744,2.477033e-7,0.6284175,0.0002311002,0.000008646903,0.007716445],"study_design_scores_gemma":[0.0002906932,0.0001026168,0.4550181,0.00001741892,0.000008878816,0.00003474617,0.000491055,0.000052742,0.5435765,0.0002458354,0.0001184186,0.00004292734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960855,0.002752103,0.0001918875,0.0005882218,0.00002483906,0.0002739395,0.0000108634,0.00001462196,0.00005808266],"genre_scores_gemma":[0.9892759,0.009758852,0.0008581333,0.00008075422,0.000008122318,0.000006484819,0.00000554146,0.000004174548,0.000002082662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09199408,"threshold_uncertainty_score":0.4714157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422048647433585,"score_gpt":0.2548233322918504,"score_spread":0.2406028458175146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}