{"id":"W2520593336","doi":"10.1038/nrc.2016.82","title":"Metabolic control of epigenetics in cancer","year":2016,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":431,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Epigenome; Epigenetics; Biology; Histone; Chromatin; Cancer cell; Chromatin remodeling; DNA methylation; Cancer; Transcription factor; Cell biology; Acetylation; Cancer research; Genetics; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006016216,0.000523116,0.002344419,0.0001609582,0.00002437782,0.00001029603,0.0004397441,0.00136069,0.0001347349],"category_scores_gemma":[0.0002428138,0.0003476093,0.000742415,0.0003467999,0.00007369815,0.000002908478,0.00008346372,0.000523829,0.00001288203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006679178,"about_ca_system_score_gemma":0.0005577138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004259989,"about_ca_topic_score_gemma":0.0002393814,"domain_scores_codex":[0.9972441,0.0004145479,0.001117472,0.0006379224,0.0002222716,0.0003636929],"domain_scores_gemma":[0.9980391,0.00005738423,0.0009419861,0.0006966803,0.0001680452,0.00009682556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007205058,0.00002699419,0.0001144573,0.005593918,0.0001493141,7.529454e-7,0.000004168558,0.000003438488,0.0008460509,0.00005281057,0.0003945352,0.9928064],"study_design_scores_gemma":[0.0003495321,0.00003795421,0.00003669645,0.01176052,0.0005178616,7.6737e-7,3.780715e-7,5.88547e-7,0.001421527,0.00002575809,0.9854626,0.0003858254],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002079022,0.9968764,0.000227105,0.00003742612,0.0007369948,0.001355109,0.000496527,0.000004318902,0.0002453387],"genre_scores_gemma":[0.0001593166,0.997187,0.0001323075,0.0001172754,0.0009744851,0.0007731531,0.0001039853,0.00008157521,0.0004708772],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9924206,"threshold_uncertainty_score":0.9999357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862197554849425,"score_gpt":0.393620243971487,"score_spread":0.3649982684229928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}