{"id":"W2520593336","doi":"10.1038/nrc.2016.82","title":"Metabolic control of epigenetics in cancer","year":2016,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":431,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Epigenome; Epigenetics; Biology; Histone; Chromatin; Cancer cell; Chromatin remodeling; DNA methylation; Cancer; Transcription factor; Cell biology; Acetylation; Cancer research; Genetics; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005847594,0.0009326031,0.001263869,0.001221951,0.0003072611,0.001146803,0.001072825,0.001424178,0.003233995],"category_scores_gemma":[0.0005825831,0.0003628148,0.0003531518,0.001953155,0.0008095194,0.001435631,0.001219691,0.001890936,0.001962261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009296922,"about_ca_system_score_gemma":0.001002545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009536617,"about_ca_topic_score_gemma":0.002031563,"domain_scores_codex":[0.9998072,0.00003568619,0.00002158275,0.00003137715,0.00007545953,0.00002881271],"domain_scores_gemma":[0.9997701,0.00008048253,0.0000424557,0.00001021078,0.00006370993,0.00003305757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001065218,0.00003731565,0.0001751337,0.008226514,0.00007368817,0.0002189804,0.00005083845,0.0005931546,0.004635797,0.009998618,0.04800382,0.9278796],"study_design_scores_gemma":[0.00001436788,0.00003593902,0.0004854726,0.001063902,0.0000539218,0.0006237828,0.00003878382,0.0001226988,0.000815278,0.005014612,0.9917143,0.00001691727],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006079351,0.9983329,0.0001514289,0.0004867286,0.000304414,0.000001639286,0.00001218585,0.000006387583,0.0006435221],"genre_scores_gemma":[0.000807272,0.9978263,0.0001226437,0.0002041588,0.0004159167,0.000002742945,0.00002361264,0.000001399319,0.0005959749],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003233995,"threshold_uncertainty_score":0.01081878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862197554849425,"score_gpt":0.393620243971487,"score_spread":0.3649982684229928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}