{"id":"W2520813766","doi":"10.1021/acs.orglett.6b02423","title":"Combining Ru-Catalyzed C–H Functionalization with Pd-Catalyzed Asymmetric Allylic Alkylation: Synthesis of 3-Allyl-3-aryl Oxindole Derivatives from Aryl α-Diazoamides","year":2016,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; University of Toronto; Alphora Research","keywords":"Chemistry; Oxindole; Catalysis; Aryl; Surface modification; Alkylation; Allylic rearrangement; Tsuji–Trost reaction; Combinatorial chemistry; Amination; Medicinal chemistry; Organic chemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001492927,0.0003876793,0.0004826204,0.0002870664,0.000164807,0.00005309053,0.0003537884,0.0001707559,0.00215018],"category_scores_gemma":[0.0004172983,0.000303014,0.0001235169,0.0007271087,0.0001522478,0.0005177758,0.0001000165,0.0001577109,0.0001669861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436866,"about_ca_system_score_gemma":0.0001333417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001137662,"about_ca_topic_score_gemma":0.00002059646,"domain_scores_codex":[0.997704,0.00003683984,0.0005751284,0.0006531446,0.0006677185,0.000363171],"domain_scores_gemma":[0.9975579,0.0008673207,0.0006031338,0.0006595809,0.0001816723,0.0001303768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001737006,0.00008749109,0.006714624,0.00007430156,0.0002874396,0.000009274358,0.0003086851,0.00001250756,0.9863514,0.0001304915,0.0001053211,0.005744799],"study_design_scores_gemma":[0.00171173,0.00001820101,0.01282682,0.0002864409,0.0001703749,0.00002163397,0.0003844628,0.00004183464,0.983803,0.0001166447,0.0001941157,0.0004247274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686677,0.0001313039,0.02864458,0.001479604,0.0001488437,0.0001666527,0.00007299185,0.0002500323,0.000438314],"genre_scores_gemma":[0.9975254,0.00005109418,0.001503494,0.0001849761,0.000210471,0.00005313963,0.0002843586,0.0001143763,0.00007271073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0288577,"threshold_uncertainty_score":0.9999422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009423580992569111,"score_gpt":0.1944835539032223,"score_spread":0.1850599729106532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}