{"id":"W2520846352","doi":"10.1016/j.bbadis.2016.09.006","title":"Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE)","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Catabolism; Pyridoxine; Lysine; Epilepsy; Chemistry; Biochemistry; Endocrinology; Internal medicine; Metabolism; Biology; Medicine; Amino acid; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678973,0.0005334413,0.0001876261,0.0005817908,0.0002357361,0.0004550797,0.000354667,0.0004286845,0.001752097],"category_scores_gemma":[0.0001598869,0.000301792,0.0003153398,0.0002245919,0.0005610727,0.0005468605,0.00029286,0.0006155804,0.000544732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004825334,"about_ca_system_score_gemma":0.0002647091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149854,"about_ca_topic_score_gemma":0.001196483,"domain_scores_codex":[0.9999114,0.00001201856,0.00001480794,0.0000297173,0.00001607482,0.00001600853],"domain_scores_gemma":[0.9997723,0.00004144222,0.00008660165,0.00002930712,0.00001263027,0.00005771582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006881703,0.00002769984,0.001206969,0.00003234707,0.00001198848,0.0003378381,0.00002427816,0.0000810739,0.9951836,0.001120291,0.00004961462,0.001235997],"study_design_scores_gemma":[0.0000505805,0.0001709241,0.01010776,0.00001058011,0.00004059261,0.001255219,0.00004558486,0.0009658077,0.9841741,0.0009632923,0.002207702,0.000007958807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884871,0.001139824,0.007434939,0.0004693325,0.00004072317,0.00002003004,0.0008012332,0.0001359281,0.001470873],"genre_scores_gemma":[0.9943396,0.000580598,0.002180106,0.00005460568,0.000007762375,0.00001694653,0.0004530593,0.00003605692,0.002331366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752097,"threshold_uncertainty_score":0.005861402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190628797833087,"score_gpt":0.2649880809906552,"score_spread":0.2530817930123244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}