{"id":"W2520866824","doi":"10.3389/fgene.2016.00161","title":"Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!","year":2016,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cell biology; Biology; Mitochondrion; Caenorhabditis elegans; Organism; Effector; Signal transduction; Homeostasis; Programmed cell death; Model organism; Mitochondrial ROS; Cell signaling; Apoptosis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005964727,0.0004702298,0.0009379344,0.0001078721,0.0001301655,0.00005134294,0.001056904,0.0004024539,0.000003336735],"category_scores_gemma":[0.0001641329,0.0002246962,0.0003713444,0.0002191337,0.0007956151,0.000002659644,0.0006282742,0.0004886379,0.000001591521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006070702,"about_ca_system_score_gemma":0.0002093557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002485397,"about_ca_topic_score_gemma":0.0000780277,"domain_scores_codex":[0.9971672,0.0008894344,0.0006957868,0.0005499652,0.0002613124,0.0004363236],"domain_scores_gemma":[0.9982924,0.000137263,0.000444643,0.001033281,0.0000376585,0.00005470851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001166319,0.00009281761,0.001819258,0.003747005,0.0004401932,0.000005340206,0.002297269,0.0006282665,0.001775951,0.0000576819,0.002801278,0.9862183],"study_design_scores_gemma":[0.003258567,0.000208858,0.0003503891,0.005028463,0.000579682,0.00002458614,0.0004246784,0.0002365885,0.008237059,0.000383809,0.9802253,0.001042025],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006789653,0.9858246,0.002344943,0.00009710214,0.003314121,0.001521979,0.00003490959,0.000005101233,0.00006759527],"genre_scores_gemma":[0.0109311,0.9868973,0.001120154,0.00007023775,0.0005425488,0.00008323295,0.00001730729,0.00008284426,0.0002552954],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9851763,"threshold_uncertainty_score":0.9162846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007641573153343687,"score_gpt":0.2273355247185601,"score_spread":0.2196939515652165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}