{"id":"W2520893324","doi":"10.1016/j.ejmech.2016.09.018","title":"Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Simon Fraser University; Genome British Columbia; Leading Edge Endowment Fund; Government of the United Kingdom; Merck Canada; Genome Canada","keywords":"Chemistry; Antimicrobial; Pyruvate kinase; Kinase; Combinatorial chemistry; Pharmacology; Stereochemistry; Biochemistry; Enzyme; Organic chemistry; Glycolysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001260019,0.0001318537,0.0003756805,0.00005058464,0.0000197525,0.000002614537,0.0002058977,0.00004771574,0.000210087],"category_scores_gemma":[0.0005759114,0.00006375065,0.0001579477,0.0001480362,0.0005460847,0.00006067483,0.00004383547,0.0002136424,0.000001475004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003377389,"about_ca_system_score_gemma":0.0001334729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006347916,"about_ca_topic_score_gemma":1.250703e-7,"domain_scores_codex":[0.9983914,0.00009471407,0.0008520739,0.0001198226,0.0004216318,0.0001203842],"domain_scores_gemma":[0.997917,0.00005217812,0.001202649,0.0001975018,0.00053184,0.0000988159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003888587,0.0000780181,0.0009924643,0.0003201232,0.00008810168,0.00002069895,0.000442855,0.000001114938,0.983602,0.000001466836,0.004187038,0.0098773],"study_design_scores_gemma":[0.002032011,0.0002649115,0.009583267,0.002592296,0.0001801736,0.00007601557,0.0001866504,0.000001775201,0.9838121,0.000002862665,0.001203616,0.00006435012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931037,0.0002307456,0.00009166072,0.005699092,0.0001965841,0.00008073198,0.00002081301,0.000003632071,0.0005730379],"genre_scores_gemma":[0.9982897,0.000158361,0.0002897623,0.0001537636,0.0008782453,3.538791e-8,0.000003066618,0.00001706899,0.000209992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009812949,"threshold_uncertainty_score":0.2599676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02975184282217379,"score_gpt":0.2436069968549081,"score_spread":0.2138551540327343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}