{"id":"W2520964432","doi":"10.1039/c6md00391e","title":"Mutual regulation and targeting of multidrug resistance and cancer stem phenotype","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"China Scholarship Council; Royal Society of Chemistry; Royal Society","keywords":"Multiple drug resistance; Phenotype; Biology; Cancer; Cancer stem cell; Resistance (ecology); Computational biology; Cancer research; Drug resistance; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000233962,0.0001768491,0.0002110736,0.0003324778,0.0001485069,0.000553074,0.0001877926,0.0003203081,0.002594832],"category_scores_gemma":[0.0002418394,0.0001743978,0.0002541925,0.0001758195,0.0002987182,0.0004136172,0.0006024721,0.0006902333,0.0004138079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002941826,"about_ca_system_score_gemma":0.0002391691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009655066,"about_ca_topic_score_gemma":0.0003504951,"domain_scores_codex":[0.9997132,0.00006851467,0.00001932742,0.00004317537,0.00008546172,0.00007029608],"domain_scores_gemma":[0.999757,0.00003880308,0.00008659677,0.00004268978,0.00002564702,0.00004921494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008937166,0.00004413338,0.0005674936,0.00004029737,0.000008200481,0.00007367325,0.00002359468,0.0001185249,0.988928,0.002375778,0.0002428294,0.00748807],"study_design_scores_gemma":[0.00003349173,0.0005515647,0.007494912,0.000009007233,0.00003033862,0.0005404857,0.00005878261,0.001810548,0.9792942,0.0007749753,0.009393919,0.000007686716],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745322,0.004680594,0.01155109,0.0007214482,0.00007409891,0.0000642845,0.0002888266,0.0003511544,0.007736187],"genre_scores_gemma":[0.9954679,0.0005202038,0.001593242,0.00006728827,0.00001352894,0.00003172864,0.0001346416,0.00001380618,0.002157595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002594832,"threshold_uncertainty_score":0.008680582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120731178071456,"score_gpt":0.2414419299565552,"score_spread":0.2293688121494096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}