{"id":"W2520964432","doi":"10.1039/c6md00391e","title":"Mutual regulation and targeting of multidrug resistance and cancer stem phenotype","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"China Scholarship Council; Royal Society of Chemistry; Royal Society","keywords":"Multiple drug resistance; Phenotype; Biology; Cancer; Cancer stem cell; Resistance (ecology); Computational biology; Cancer research; Drug resistance; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885608,0.00009981643,0.0002347255,0.00003869682,0.00004568802,0.000003528153,0.00003310135,0.00006010931,0.00006925203],"category_scores_gemma":[0.00001935151,0.00006294867,0.00002556138,0.00006571549,0.0001327262,0.00006181338,0.0000145281,0.00005277514,0.000002026469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002450783,"about_ca_system_score_gemma":0.00002734363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001839691,"about_ca_topic_score_gemma":0.00008181752,"domain_scores_codex":[0.9992799,0.00001626699,0.0002115767,0.0001861109,0.0001646186,0.0001414985],"domain_scores_gemma":[0.9995775,0.00004970708,0.00008694488,0.0001388565,0.00006588174,0.00008111359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005846719,0.00005087108,0.0451662,0.0005589115,0.00005775913,0.00001004074,0.001141189,2.81949e-7,0.9112427,0.001876518,0.0009447969,0.03836605],"study_design_scores_gemma":[0.004259945,0.00007954993,0.1207583,0.001597858,0.0001648162,0.000004602307,0.0004438417,0.0001031911,0.8452889,0.001069566,0.02594104,0.000288462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913214,0.004049255,0.0009110169,0.002055302,0.0001010896,0.000185926,0.00001565148,0.00003647963,0.001323821],"genre_scores_gemma":[0.9892953,0.000492309,0.002373365,0.00004575187,0.00007166676,0.000009405566,0.000004238982,0.00001616139,0.007691769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07559208,"threshold_uncertainty_score":0.2566972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120731178071456,"score_gpt":0.2414419299565552,"score_spread":0.2293688121494096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}