{"id":"W2520968410","doi":"10.1371/journal.pgen.1006217","title":"Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Weill Cornell Medical College; College of Veterinary Medicine, Cornell University; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Lunds Universitet; Cancerfonden; York University; Karolinska Institutet; New York University Abu Dhabi","keywords":"Biology; Ribosome biogenesis; RNA polymerase I; Transcription (linguistics); Wnt signaling pathway; RNA polymerase II; Cell biology; Promoter; Genetics; Signal transduction; Gene expression; Gene; RNA; RNA polymerase; Ribosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009272885,0.0002453351,0.0001842652,0.00002989737,0.00009034033,0.00003319185,0.0003238787,0.0001974709,0.0002499036],"category_scores_gemma":[0.00003611545,0.0001973315,0.00009575117,0.00009962522,0.00007279565,0.000007236325,0.00008451197,0.00005577575,0.00009080755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002772768,"about_ca_system_score_gemma":0.00007191512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004939015,"about_ca_topic_score_gemma":0.000005614477,"domain_scores_codex":[0.9983835,0.00006013349,0.0003096178,0.0005566161,0.0002804062,0.0004097723],"domain_scores_gemma":[0.9992271,0.0000148937,0.00007775959,0.0004151368,0.0001123398,0.0001527594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001044092,0.00008204946,0.000475923,0.0000118342,0.00009198405,0.000002205718,0.000132584,0.0000152461,0.9710566,0.00001053883,0.02504895,0.002967678],"study_design_scores_gemma":[0.0006002881,0.0002287888,0.00008094698,0.00004556868,0.00003932653,0.000003027991,0.00002021021,0.000007865956,0.9407659,0.0001069768,0.05775491,0.0003461606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887552,0.003143024,0.005354198,0.0008939179,0.0002736184,0.0002725036,0.0001178305,0.00003687596,0.001152812],"genre_scores_gemma":[0.9923251,0.0006748762,0.001192489,0.001141167,0.0004300213,0.00008318651,0.00008546714,0.00005413601,0.004013532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03270596,"threshold_uncertainty_score":0.8046945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757721720192876,"score_gpt":0.2453819342813282,"score_spread":0.2278047170793995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}