{"id":"W2520968410","doi":"10.1371/journal.pgen.1006217","title":"Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Weill Cornell Medical College; College of Veterinary Medicine, Cornell University; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Lunds Universitet; Cancerfonden; York University; Karolinska Institutet; New York University Abu Dhabi","keywords":"Biology; Ribosome biogenesis; RNA polymerase I; Transcription (linguistics); Wnt signaling pathway; RNA polymerase II; Cell biology; Promoter; Genetics; Signal transduction; Gene expression; Gene; RNA; RNA polymerase; Ribosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231077,0.0004145484,0.0001969804,0.0002537363,0.0001856025,0.000466413,0.0002177009,0.0002275757,0.002170692],"category_scores_gemma":[0.0001188724,0.0002328353,0.0002881206,0.0001922535,0.0002570939,0.0002233137,0.0002870957,0.0006403478,0.0006798391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008607276,"about_ca_system_score_gemma":0.0004615601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002627712,"about_ca_topic_score_gemma":0.00667131,"domain_scores_codex":[0.9998122,0.0000240138,0.00001824144,0.00004541833,0.000058347,0.00004173158],"domain_scores_gemma":[0.9999382,0.000004768736,0.00002514224,0.000006454094,0.000007638069,0.00001769833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005473094,0.000005304913,0.0002548602,0.00005940919,0.000004795919,0.00004514009,0.000008890381,0.00004474636,0.9977103,0.0003576196,0.00007170998,0.001382421],"study_design_scores_gemma":[0.00001894286,0.00006928978,0.0056077,0.00001336687,0.00001495426,0.0002099584,0.00002704284,0.0008952545,0.979704,0.0001020689,0.01333242,0.000005033653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465168,0.02049591,0.01612791,0.0008067949,0.0002247928,0.00008818718,0.002951727,0.0005811345,0.01220693],"genre_scores_gemma":[0.9799672,0.004191557,0.003828038,0.0001431741,0.00001682927,0.00003893774,0.001505886,0.00005161148,0.01025683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002627712,"threshold_uncertainty_score":0.007261634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757721720192876,"score_gpt":0.2453819342813282,"score_spread":0.2278047170793995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}