{"id":"W2520995945","doi":"10.1007/s00253-016-7829-5","title":"Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application","year":2016,"lang":"en","type":"review","venue":"Applied Microbiology and Biotechnology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Escherichia coli; Plasmid; Probiotic; Biology; Recombinant DNA; Strain (injury); Microbiology; Biotechnology; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003940736,0.0004573565,0.001416426,0.0001566503,0.00008957138,0.000005978285,0.0004976816,0.002443064,0.000002467035],"category_scores_gemma":[0.0001774188,0.0003464297,0.0002835651,0.0001735058,0.0008502803,0.00000135452,0.00055707,0.0003852439,0.0000126038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002215891,"about_ca_system_score_gemma":0.0001938735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001553702,"about_ca_topic_score_gemma":0.000004386527,"domain_scores_codex":[0.9976554,0.00007706181,0.0007958964,0.0009343703,0.00003058824,0.0005067158],"domain_scores_gemma":[0.9985996,0.0001841257,0.0004451716,0.0006337108,0.00007434344,0.00006299336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004693884,0.00007920837,0.00001210198,0.00343286,0.0005879653,6.385158e-7,0.000002504629,1.688741e-7,0.6872314,0.002028828,0.0006596273,0.3059178],"study_design_scores_gemma":[0.0004929228,0.0004188981,0.000006635163,0.00033146,0.0002125641,0.00002549966,0.00000456445,0.000001842949,0.01853749,0.00003487096,0.979565,0.00036822],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002237644,0.9888995,0.006048087,0.00008085031,0.0001425823,0.00230053,0.0002070022,0.00005126519,0.00003259506],"genre_scores_gemma":[0.001639619,0.9902667,0.006646522,0.0000409829,0.0002052343,0.0008577882,0.0001812817,0.00006539518,0.00009645995],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9789054,"threshold_uncertainty_score":0.9998988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119547958701753,"score_gpt":0.3182664825961468,"score_spread":0.2970710030091293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}