{"id":"W2521151298","doi":"10.1038/srep33869","title":"Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Gene silencing; Transplantation; Signal transduction; Gene; Heart transplantation; Cancer research; Medicine; Immunology; Biology; Bioinformatics; Cell biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001247982,0.00008413141,0.000250786,0.0001622487,0.00004511278,0.000009591134,0.00001902767,0.00005289691,0.0000234377],"category_scores_gemma":[0.00006367034,0.00006034374,0.00007764356,0.0002396574,0.0001268471,0.0001725867,0.000004912819,0.00004569947,3.265382e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002518965,"about_ca_system_score_gemma":0.0000904317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006606,"about_ca_topic_score_gemma":0.0000371742,"domain_scores_codex":[0.9985467,0.00008238787,0.0006244002,0.0003259056,0.0002954376,0.0001251897],"domain_scores_gemma":[0.9993107,0.00008734238,0.0002684772,0.0001816425,0.000110848,0.00004100206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004481226,0.00006650106,0.05665933,0.0003237371,0.00001043107,0.00006127331,0.00175137,0.00001667134,0.9339833,0.00005414586,0.00001056875,0.007017918],"study_design_scores_gemma":[0.0007611028,0.0001306862,0.08706728,0.0009434874,0.00008231681,0.0002809742,0.0001906786,0.00002202757,0.908612,0.00177379,0.00006571288,0.00006994786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766479,0.0002664966,0.02157732,0.00008141492,0.001058227,0.0003013387,0.000006762337,0.0000163493,0.00004415837],"genre_scores_gemma":[0.9895429,0.0001134998,0.01019052,0.000006643232,0.00002066116,0.000008297001,0.00002726364,0.000006740003,0.00008345953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03040796,"threshold_uncertainty_score":0.2460746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04384228612620025,"score_gpt":0.3220198078888816,"score_spread":0.2781775217626813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}