{"id":"W2521151298","doi":"10.1038/srep33869","title":"Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Gene silencing; Transplantation; Signal transduction; Gene; Heart transplantation; Cancer research; Medicine; Immunology; Biology; Bioinformatics; Cell biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000340438,0.0003454908,0.0004178598,0.0002299404,0.0001408926,0.0003234886,0.0002383421,0.0002301284,0.0008122497],"category_scores_gemma":[0.0001518308,0.0001621053,0.0002730802,0.000108927,0.0002384473,0.000230574,0.0002417296,0.0006611033,0.0002098827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001141902,"about_ca_system_score_gemma":0.0002486399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001058101,"about_ca_topic_score_gemma":0.0002669272,"domain_scores_codex":[0.9997807,0.00003726896,0.00002458367,0.00004251041,0.00006076132,0.00005412579],"domain_scores_gemma":[0.99989,0.00001754293,0.00004029984,0.00001413444,0.00001233119,0.00002583254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003901883,0.0002229652,0.0001935362,0.00007767351,0.00001025933,0.00003186007,0.0000180737,0.0000937624,0.99356,0.0001189564,0.00003906507,0.005243677],"study_design_scores_gemma":[0.000109145,0.003724081,0.003118018,0.0000134711,0.00006359781,0.0003117981,0.00002476613,0.001032328,0.9898399,0.00006667148,0.001689345,0.000006863102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927633,0.001822635,0.004137131,0.00007868171,0.00006572724,0.00007559591,0.00006101264,0.00008854661,0.0009073578],"genre_scores_gemma":[0.9933809,0.001084263,0.003845196,0.00005571617,0.00004066257,0.0001044748,0.000115958,0.00001726227,0.001355501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008122497,"threshold_uncertainty_score":0.002717316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04384228612620025,"score_gpt":0.3220198078888816,"score_spread":0.2781775217626813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}