{"id":"W2521254149","doi":"10.1091/mbc.e15-11-0757","title":"Dynein-mediated trafficking negatively regulates LET-23 EGFR signaling","year":2016,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; University of California, San Diego; National Institutes of Health; Canadian Institutes of Health Research; McGill University Health Centre; Cancer Research Society; McGill University; University of Minnesota","keywords":"Biology; Dynein; Cell biology; Rab; Endosome; Caenorhabditis elegans; Microtubule; Signal transduction; Epidermal growth factor receptor; GTPase; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006420887,0.0003352306,0.000184422,0.0002056157,0.0003198466,0.0004362512,0.0002456675,0.0002716934,0.0008037672],"category_scores_gemma":[0.0001036159,0.0001584637,0.0001455407,0.00007261061,0.0002445292,0.0001614626,0.0002294872,0.000402866,0.0004075809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007418494,"about_ca_system_score_gemma":0.0003215242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001545314,"about_ca_topic_score_gemma":0.00296478,"domain_scores_codex":[0.9998876,0.00001145258,0.000008108567,0.00002379738,0.0000410627,0.00002809118],"domain_scores_gemma":[0.9998692,0.00002462236,0.00004166508,0.0000107365,0.00001733888,0.00003640517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002251668,0.00000559835,0.0002253455,0.000007801739,0.000001344154,0.0000655632,0.000004700321,0.00002914092,0.9991992,0.0000869998,0.00002525061,0.0003266529],"study_design_scores_gemma":[0.000004853325,0.00003358866,0.007410448,0.000004253305,0.000008009628,0.0002862692,0.00002151007,0.0006537078,0.9897277,0.00004643371,0.001798537,0.000004713964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961605,0.0009871039,0.0008884486,0.00008693422,0.00001681199,0.000008641146,0.0001540854,0.00007312892,0.001624281],"genre_scores_gemma":[0.9978358,0.0003764399,0.0003991841,0.00003121935,0.000002826261,0.000006076541,0.0001478809,0.00001541544,0.001185119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001545314,"threshold_uncertainty_score":0.005382538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005146415388231573,"score_gpt":0.2132237114487695,"score_spread":0.208077296060538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}