{"id":"W2521319993","doi":"10.1002/ddr.21341","title":"Lithium Pharmacogenetics: Where Do We Stand?","year":2016,"lang":"en","type":"review","venue":"Drug Development Research","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Lithium (medication); Ebselen; Pharmacogenetics; Repurposing; Medicine; Pharmacology; Bipolar disorder; Population; Treatment of bipolar disorder; Computational biology; Bioinformatics; Genetics; Psychiatry; Biology; Internal medicine; Glutathione peroxidase; Genotype; Oxidative stress; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001567737,0.0005885587,0.001475849,0.0007358416,0.0002942244,0.00009776474,0.0004522244,0.0003148297,0.002459294],"category_scores_gemma":[0.00005018062,0.000354262,0.000351197,0.0006692802,0.0001704848,0.00004639686,0.0004381125,0.001080523,0.005550966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001006129,"about_ca_system_score_gemma":0.005276499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000081834,"about_ca_topic_score_gemma":0.00001775337,"domain_scores_codex":[0.9950647,0.0004821164,0.0007584396,0.0008816632,0.001714922,0.001098103],"domain_scores_gemma":[0.9978629,0.000342392,0.000115593,0.0007248974,0.0004158854,0.0005383698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002445418,0.0002683643,0.0001665867,0.02698041,0.0008161601,0.00008947965,0.000341138,2.066382e-9,8.787289e-7,0.00003404063,0.02257841,0.9487001],"study_design_scores_gemma":[0.0009316889,0.00005253399,0.00002779408,0.04499531,0.000254256,0.00006359628,0.00005684745,1.29136e-7,0.00005430031,0.00003422172,0.9531679,0.0003614885],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002372778,0.9845127,0.00001616007,0.0008150042,0.0002132423,0.002237645,0.00005435752,0.0000777447,0.01207079],"genre_scores_gemma":[0.000003232045,0.9235377,0.0009735515,0.000005293041,0.0002577731,0.0007053907,0.00007302892,0.0001261241,0.07431789],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9483386,"threshold_uncertainty_score":0.9998909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1310713958498368,"score_gpt":0.4559046131439752,"score_spread":0.3248332172941384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}