{"id":"W2521325152","doi":"10.1073/pnas.1604082113","title":"Molecular mechanism of Zn <sup>2+</sup> inhibition of a voltage-gated proton channel","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Biophysics; Protein subunit; Biochemistry; Stereochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716133,0.0004081252,0.0003636761,0.0001389155,0.0002347953,0.0003366736,0.0005730223,0.0005081585,0.00137217],"category_scores_gemma":[0.0001427828,0.000151656,0.000320367,0.00006114077,0.0004181454,0.0003296988,0.0002803181,0.0004552471,0.0003513815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004359962,"about_ca_system_score_gemma":0.0002286368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000613838,"about_ca_topic_score_gemma":0.0004519025,"domain_scores_codex":[0.9998854,0.00002102079,0.000009252962,0.00002434634,0.00002930708,0.00003061927],"domain_scores_gemma":[0.9999408,0.00001133451,0.00001885672,0.000006619469,0.00001081909,0.00001159212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004914794,0.00004963992,0.0004585012,0.0001660694,0.00001951638,0.0003584255,0.00002406568,0.0008412587,0.9929052,0.001603229,0.000305885,0.002776825],"study_design_scores_gemma":[0.0001680081,0.0003691253,0.006526556,0.00001395275,0.00003809917,0.001120179,0.0000632052,0.01448718,0.9717533,0.001172849,0.004264184,0.00002342331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963326,0.007177486,0.02086214,0.001379776,0.0002196675,0.0001093834,0.0004860621,0.000663146,0.005776428],"genre_scores_gemma":[0.9946088,0.001447433,0.002473549,0.0001281936,0.00002052391,0.00002899294,0.0001393325,0.00001316586,0.001140011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00137217,"threshold_uncertainty_score":0.004590333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186158579511832,"score_gpt":0.2635960167185082,"score_spread":0.2417344309233899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}