{"id":"W2521326903","doi":"10.1038/srep33298","title":"Functional Recovery of AQP2 Recessive Mutations Through Hetero-Oligomerization with Wild-Type Counterpart","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Mutant; Aquaporin 2; Nephrogenic diabetes insipidus; Mutation; Heterozygote advantage; Xenopus; Biology; Wild type; Intracellular; Cell biology; Compound heterozygosity; HEK 293 cells; Genetics; Kidney; Chemistry; Gene; Water channel; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963198,0.0003620002,0.0002612357,0.0002728748,0.0001498534,0.0002836456,0.0002790659,0.0002864832,0.001240466],"category_scores_gemma":[0.0002157076,0.0001324584,0.0003144014,0.0001275683,0.0002807961,0.0002010609,0.0003076331,0.0005609107,0.0006492943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863616,"about_ca_system_score_gemma":0.0001311393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003822762,"about_ca_topic_score_gemma":0.0004101897,"domain_scores_codex":[0.9997424,0.00003830159,0.00003615281,0.00006837078,0.00007860159,0.00003614678],"domain_scores_gemma":[0.9998254,0.00003065126,0.00005104874,0.00003241397,0.0000145922,0.00004596216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003018573,0.00001403982,0.00007403806,0.000008027476,0.000003728405,0.00008260268,0.00000962881,0.00003093653,0.9992373,0.00006257576,0.00002198577,0.000425054],"study_design_scores_gemma":[0.00001582114,0.0001852775,0.004346624,0.000004969196,0.00002554455,0.001883472,0.00004534238,0.001417692,0.9903094,0.00008343988,0.001671626,0.0000107559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928752,0.0003036364,0.005220279,0.00007677189,0.00002837141,0.00002118247,0.0003059204,0.0001429109,0.00102574],"genre_scores_gemma":[0.9956917,0.0002245615,0.001747499,0.00004327577,0.000007485311,0.00002449006,0.0003286652,0.0001231354,0.001809302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001240466,"threshold_uncertainty_score":0.004149735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066851358535857,"score_gpt":0.2254597329570321,"score_spread":0.2147912193716735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}