{"id":"W2521326903","doi":"10.1038/srep33298","title":"Functional Recovery of AQP2 Recessive Mutations Through Hetero-Oligomerization with Wild-Type Counterpart","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Mutant; Aquaporin 2; Nephrogenic diabetes insipidus; Mutation; Heterozygote advantage; Xenopus; Biology; Wild type; Intracellular; Cell biology; Compound heterozygosity; HEK 293 cells; Genetics; Kidney; Chemistry; Gene; Water channel; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166268,0.00008785184,0.00009012807,0.00004657084,0.0001091781,0.00002354015,0.00004220055,0.00006810373,0.00008888623],"category_scores_gemma":[0.00002947625,0.00005932858,0.00004404721,0.0001878377,0.0002058264,0.00002715386,0.00001068987,0.00001884841,0.000006402463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001203744,"about_ca_system_score_gemma":0.0001324609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004792601,"about_ca_topic_score_gemma":0.00002037417,"domain_scores_codex":[0.998975,0.00001618606,0.0002676472,0.0003729157,0.0002469594,0.0001212819],"domain_scores_gemma":[0.9990147,0.000005430372,0.0002540776,0.0003140428,0.0003798943,0.00003186867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111788,0.00003887247,0.005713799,0.00001063052,0.00003365972,0.000007952834,0.00006848614,0.0004329141,0.9903641,0.0000385643,0.002591005,0.0005882007],"study_design_scores_gemma":[0.0002890495,0.000222244,0.00647172,0.00006640033,0.00003000804,0.000097157,0.00005949243,0.00001008567,0.9534433,0.001642466,0.03750392,0.0001641847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778484,0.00006585433,0.01879872,0.0001119112,0.002443122,0.0001313645,0.00001023448,0.00001168454,0.0005787414],"genre_scores_gemma":[0.9937806,0.00001968714,0.0002778436,0.00002354408,0.00009964848,0.00001104218,0.0009676544,0.00001109764,0.004808851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03692085,"threshold_uncertainty_score":0.2419349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066851358535857,"score_gpt":0.2254597329570321,"score_spread":0.2147912193716735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}