{"id":"W2521380866","doi":"10.2174/1381612822666160921143011","title":"Engineered Autonomous Human Variable Domains","year":2016,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Antibody; Single-domain antibody; Epitope; Phage display; Computational biology; Computer science; Complementarity determining region; Protein engineering; Chemistry; Immunoglobulin light chain; Biology; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003241187,0.0003546664,0.0002508493,0.0003562942,0.00008556611,0.0003571478,0.0004238547,0.0004077639,0.001259274],"category_scores_gemma":[0.0002658921,0.0001235013,0.00027967,0.0003261073,0.0002343668,0.0003120328,0.0002859742,0.0005517264,0.0008154654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004329838,"about_ca_system_score_gemma":0.0002450244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003532979,"about_ca_topic_score_gemma":0.0003042946,"domain_scores_codex":[0.99989,0.00001818356,0.000007598142,0.00002547129,0.00003810639,0.00002060436],"domain_scores_gemma":[0.9999392,0.0000148409,0.00001961795,0.000004040494,0.00001367635,0.000008558165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002239756,0.0001998535,0.001055515,0.007023924,0.0001260016,0.0007339027,0.000154563,0.003124746,0.3993375,0.0282459,0.01187815,0.547896],"study_design_scores_gemma":[0.00005160997,0.0003400092,0.001133098,0.0004657491,0.000088728,0.002313071,0.00002769917,0.0009462957,0.1944014,0.001505045,0.7986988,0.00002848651],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08497892,0.8382585,0.03591772,0.001212344,0.0009324953,0.000203319,0.000793624,0.0003026669,0.03740039],"genre_scores_gemma":[0.4336034,0.5043069,0.03290966,0.001297766,0.0001965271,0.0002404539,0.001687355,0.00006469087,0.02569326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001259274,"threshold_uncertainty_score":0.004212677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.27784377078503,"score_gpt":0.4958777636993394,"score_spread":0.2180339929143094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}