{"id":"W2521380866","doi":"10.2174/1381612822666160921143011","title":"Engineered Autonomous Human Variable Domains","year":2016,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Antibody; Single-domain antibody; Epitope; Phage display; Computational biology; Computer science; Complementarity determining region; Protein engineering; Chemistry; Immunoglobulin light chain; Biology; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0007235525,0.0007702944,0.002213249,0.0003509368,0.0001959861,0.00006218743,0.0004923324,0.0003752918,0.00379857],"category_scores_gemma":[0.0001507665,0.0004772887,0.0007985468,0.0004354034,0.0002631955,0.00007392603,0.0002395511,0.001516622,0.002798575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499723,"about_ca_system_score_gemma":0.0009116039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000133193,"about_ca_topic_score_gemma":1.993229e-8,"domain_scores_codex":[0.9960008,0.0004565835,0.0009242223,0.0007960063,0.0007251035,0.001097239],"domain_scores_gemma":[0.9972744,0.0008369065,0.0001517077,0.0005463223,0.0001355441,0.001055105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007086234,0.000375392,0.000001474586,0.02319509,0.0004400473,0.0001389438,0.000006683345,2.176386e-7,0.00007388114,0.007365151,0.01540786,0.9529244],"study_design_scores_gemma":[0.0009149658,0.0002274892,0.000001388111,0.01641258,0.001298478,0.0002483054,4.386474e-7,0.00008580251,0.00004422987,0.0002934264,0.9799334,0.0005395402],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[7.59707e-7,0.983712,0.00879283,0.0001268795,0.0008808752,0.002000343,0.0001888679,0.000190789,0.004106718],"genre_scores_gemma":[0.000005620353,0.9899129,0.00111795,0.00007482289,0.00168804,0.0002902198,0.0002667578,0.0001216232,0.006522022],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9645255,"threshold_uncertainty_score":0.9997679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.27784377078503,"score_gpt":0.4958777636993394,"score_spread":0.2180339929143094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}