{"id":"W2521395398","doi":"10.1159/000448894","title":"Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation","year":2016,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jenny ja Antti Wihurin Rahasto; Canadian Institutes of Health Research; Wihuri Research Institute; Helsingin ja Uudenmaan Sairaanhoitopiiri; Ida Montinin Säätiö","keywords":"Inflammasome; COPP; Hemin; Autophagy; Proinflammatory cytokine; Cell biology; Chemistry; Caspase 1; Inflammation; Biology; Heme; Apoptosis; Biochemistry; Heme oxygenase; Immunology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009684777,0.0002182404,0.0002973169,0.0001314761,0.0001054922,0.0002174293,0.0001481426,0.0002810977,0.0005218767],"category_scores_gemma":[0.00007465732,0.00006850199,0.0001506437,0.0001102361,0.0002223667,0.0002438252,0.0001936885,0.0002629378,0.00009958273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861272,"about_ca_system_score_gemma":0.0001532517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002167823,"about_ca_topic_score_gemma":0.0003356577,"domain_scores_codex":[0.9999372,0.00001443447,0.000006369411,0.00001304248,0.00001344977,0.00001556243],"domain_scores_gemma":[0.9999572,0.000007264057,0.00001432973,0.000005471717,0.000003987507,0.00001176934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000829606,0.00008398464,0.000205293,0.0001143628,0.00001672699,0.0001327602,0.00001727868,0.0001008071,0.9940275,0.0002252517,0.0001000256,0.004146458],"study_design_scores_gemma":[0.0001018671,0.0006218692,0.003045552,0.000005206079,0.0000186585,0.0003835789,0.00001315818,0.0005743834,0.9924273,0.0001020083,0.002702157,0.00000422903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849814,0.006163308,0.006148573,0.0002824332,0.00006043125,0.0000491776,0.0001571551,0.0001101663,0.002047375],"genre_scores_gemma":[0.9944588,0.001548928,0.002211975,0.00008111767,0.00002153036,0.00003776397,0.00009953846,0.00001140143,0.00152894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005218767,"threshold_uncertainty_score":0.00174582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00552703252276496,"score_gpt":0.2164039402870436,"score_spread":0.2108769077642786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}