{"id":"W2521395398","doi":"10.1159/000448894","title":"Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation","year":2016,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jenny ja Antti Wihurin Rahasto; Canadian Institutes of Health Research; Wihuri Research Institute; Helsingin ja Uudenmaan Sairaanhoitopiiri; Ida Montinin Säätiö","keywords":"Inflammasome; COPP; Hemin; Autophagy; Proinflammatory cytokine; Cell biology; Chemistry; Caspase 1; Inflammation; Biology; Heme; Apoptosis; Biochemistry; Heme oxygenase; Immunology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008410877,0.0001991633,0.0002965703,0.0001552508,0.00009751075,0.00002244895,0.000212345,0.0002155325,0.00002399219],"category_scores_gemma":[0.0003778029,0.0001528515,0.0001152297,0.0001413283,0.0001156477,0.00007715543,0.0001433564,0.0002046686,0.000001398838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004849949,"about_ca_system_score_gemma":0.0001452093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002321113,"about_ca_topic_score_gemma":0.000007090403,"domain_scores_codex":[0.9984799,0.0000960659,0.0007974803,0.0001560949,0.0002461021,0.0002243601],"domain_scores_gemma":[0.9982023,0.00003754599,0.000982379,0.0002795841,0.0004325155,0.00006563625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003537008,0.00008870348,0.0003989557,0.00004637924,0.00009001427,8.855187e-7,0.0001802575,0.000005440009,0.992617,0.0003866864,0.0001121874,0.005719752],"study_design_scores_gemma":[0.002133134,0.000551892,0.004836084,0.0002332449,0.00002106884,0.00003840311,0.0001544001,0.00001078708,0.9888964,0.0006977016,0.002241291,0.0001855625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928823,0.0002774346,0.005977625,0.0002762694,0.00009497027,0.0002964742,0.00001159934,0.000006332733,0.0001769727],"genre_scores_gemma":[0.9987709,0.0002889678,0.0004753472,0.00005478192,0.00008456659,0.00001186144,0.00002148137,0.00002328824,0.0002688094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005888574,"threshold_uncertainty_score":0.6233101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00552703252276496,"score_gpt":0.2164039402870436,"score_spread":0.2108769077642786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}