{"id":"W2521615731","doi":"10.1016/j.neo.2016.07.004","title":"Induction of Activating Transcription Factor 3 Is Associated with Cisplatin Responsiveness in Non–Small Cell Lung Carcinoma Cells","year":2016,"lang":"en","type":"article","venue":"Neoplasia","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ontario Institute for Cancer Research; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Cisplatin; Cytotoxicity; Cancer research; Biology; Transcriptome; Cell culture; Lung cancer; ATF3; Vorinostat; Activating transcription factor; Transcription factor; Pharmacology; Histone deacetylase; Gene expression; Medicine; Chemotherapy; Histone; Oncology; In vitro; Biochemistry; Gene; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807339,0.0001487927,0.0001783943,0.0001333381,0.00004421186,0.000008310736,0.0001144868,0.0002366654,0.00002478642],"category_scores_gemma":[0.00008809452,0.0001172188,0.00005419794,0.0002079393,0.00006243264,0.0000105659,0.00002676021,0.0001340647,0.000004841513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112835,"about_ca_system_score_gemma":0.0001777297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008478449,"about_ca_topic_score_gemma":0.0002012852,"domain_scores_codex":[0.9988056,0.0001488819,0.0002398679,0.0003335224,0.0002070853,0.0002650831],"domain_scores_gemma":[0.9993615,0.00005474194,0.000137726,0.0002317919,0.000153971,0.00006025727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003971289,0.0001540155,0.01097897,0.00003579781,0.000014943,0.000007936608,0.0005151741,0.000008038014,0.9862647,6.395531e-7,0.000175554,0.001447116],"study_design_scores_gemma":[0.002709039,0.0003117603,0.03096326,0.0001176037,0.000006462585,0.000004086804,0.0001043532,0.00003998928,0.9653934,0.000001365969,0.0002033305,0.0001453722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985228,0.00003968207,0.0006793331,0.00004984311,0.00007869047,0.0002805394,0.00005967762,0.000007031775,0.000282459],"genre_scores_gemma":[0.9988376,0.00001164715,0.0001327197,0.0000156499,0.00005008611,0.00002315664,0.00002600545,0.00002974226,0.0008733555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0208713,"threshold_uncertainty_score":0.4780045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209053255255826,"score_gpt":0.2396768559164087,"score_spread":0.2275863233638505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}