{"id":"W2521639558","doi":"10.1182/blood.v126.23.2807.2807","title":"Demographics, Baseline Characteristics, and Disease Symptom Burden in RESPONSE-2: A Randomized, Phase 3 Study of Ruxolitinib in Polycythemia Vera Patients (pts) Who Are Resistant to or Intolerant of Hydroxyurea (HU)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Ruxolitinib; Internal medicine; Polycythemia vera; Phlebotomy; Myeloproliferative neoplasm; Thrombocytosis; Quality of life (healthcare); Anemia; Gastroenterology; Myelofibrosis; Bone marrow; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001785641,0.0009597712,0.001583111,0.0002809578,0.0004908901,0.0008493463,0.000552855,0.001133043,0.003498604],"category_scores_gemma":[0.001152687,0.0004849212,0.001252901,0.0003223523,0.0005889435,0.0009021595,0.0003299438,0.002676958,0.0005544553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005086845,"about_ca_system_score_gemma":0.000716473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003994381,"about_ca_topic_score_gemma":0.0008379774,"domain_scores_codex":[0.9993328,0.0003787138,0.00003328437,0.00009590885,0.00005755532,0.0001017396],"domain_scores_gemma":[0.9993117,0.0001375946,0.0001812739,0.0000463466,0.00004552053,0.0002775643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8956994,0.04055503,0.02041203,0.0004686871,0.001379655,0.0001856445,0.0001540582,0.0008155403,0.01006828,0.000109888,0.001767318,0.02838445],"study_design_scores_gemma":[0.7431418,0.2132013,0.03945417,0.00002684564,0.000701867,0.0002392135,0.00006982061,0.001135209,0.0009259565,0.0001469705,0.0009284329,0.00002853123],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966211,0.0006393584,0.0001821046,0.0001987037,0.00003985452,0.001271538,0.0005488912,0.00002872275,0.0004697682],"genre_scores_gemma":[0.995532,0.0002919355,0.0004497086,0.0005210476,0.0001094716,0.001713598,0.0008256047,0.000008101813,0.0005484676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003498604,"threshold_uncertainty_score":0.01170403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01898396108697531,"score_gpt":0.2917810544879017,"score_spread":0.2727970934009264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}