{"id":"W2521726183","doi":"10.1016/s2468-1253(16)30107-8","title":"Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial","year":2016,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":546,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Liver Centre","funders":"U.S. Food and Drug Administration; Gilead Sciences","keywords":"Tenofovir alafenamide; Tenofovir; Medicine; Double blind; Virology; Chronic hepatitis; Internal medicine; Virus; Human immunodeficiency virus (HIV); Placebo; Viral load; Antiretroviral therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001737601,0.001753302,0.00305842,0.0003921481,0.0004282201,0.001058409,0.0008851561,0.001850365,0.005795802],"category_scores_gemma":[0.001833596,0.0005985838,0.002371964,0.0003763798,0.001071341,0.0009862131,0.0003599267,0.002517322,0.0007724561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008374689,"about_ca_system_score_gemma":0.0008915183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142639,"about_ca_topic_score_gemma":0.002904124,"domain_scores_codex":[0.9992925,0.0004150009,0.00004927645,0.0000915157,0.00004732321,0.0001043528],"domain_scores_gemma":[0.9991611,0.0003471551,0.0001748659,0.00005637894,0.00004852712,0.0002120439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9851908,0.001109011,0.0002136304,0.0009268338,0.001182903,0.0000348586,0.00003987361,0.0001692722,0.001415944,0.00008548104,0.0003739827,0.009257464],"study_design_scores_gemma":[0.9801418,0.01772502,0.0007249957,0.00005398998,0.0005141012,0.0000265533,0.00002010294,0.0001568839,0.0001880165,0.0001223442,0.0003162207,0.00001001137],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726739,0.01903831,0.0007720102,0.001151181,0.001208319,0.001843247,0.0008915147,0.0001127381,0.002308745],"genre_scores_gemma":[0.9878714,0.005667725,0.0009370802,0.0008009758,0.0004075223,0.001475433,0.0005289426,0.00001662027,0.002294092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005795802,"threshold_uncertainty_score":0.01938891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03931133987802224,"score_gpt":0.3177370063624477,"score_spread":0.2784256664844255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}