{"id":"W2521726183","doi":"10.1016/s2468-1253(16)30107-8","title":"Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial","year":2016,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":546,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Liver Centre","funders":"U.S. Food and Drug Administration; Gilead Sciences","keywords":"Tenofovir alafenamide; Tenofovir; Medicine; Double blind; Virology; Chronic hepatitis; Internal medicine; Virus; Human immunodeficiency virus (HIV); Placebo; Viral load; Antiretroviral therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004952051,0.0006991185,0.00226423,0.0001933075,0.0005325647,0.00002100958,0.0003539317,0.0002787723,0.0001115827],"category_scores_gemma":[0.0001554108,0.0003344284,0.0005049667,0.000232329,0.00178546,0.0001546591,0.0001271311,0.000321095,0.00003983525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007654737,"about_ca_system_score_gemma":0.0003915651,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005974561,"about_ca_topic_score_gemma":0.1295599,"domain_scores_codex":[0.9959089,0.0004858778,0.00108624,0.0008432906,0.0003685566,0.00130711],"domain_scores_gemma":[0.9957155,0.001607931,0.0008344536,0.001127273,0.0005243492,0.0001904744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5023755,0.001258571,0.4903567,0.00003723654,0.001743842,0.00002024505,0.0002237939,0.000004284454,0.0001515745,0.00001879512,0.0004801252,0.003329341],"study_design_scores_gemma":[0.7672381,0.05491389,0.1692239,0.00006254466,0.001520943,0.00003614611,0.000009570981,0.0002492535,0.0006161393,0.0000486254,0.005861055,0.0002197936],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798743,0.0002345278,0.004758607,0.004202058,0.001749821,0.008485986,0.0005159305,0.00009685901,0.0000818831],"genre_scores_gemma":[0.9885767,0.004180841,0.0001480754,0.0005208569,0.001245904,0.005035816,0.00008660343,0.00007570942,0.0001295487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3211327,"threshold_uncertainty_score":0.9999108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03931133987802224,"score_gpt":0.3177370063624477,"score_spread":0.2784256664844255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}