{"id":"W2521905552","doi":"10.1002/anie.201607483","title":"Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"In vivo; Mass cytometry; Oxygenation; Chemistry; Hypoxia (environmental); Biophysics; Cell biology; Flow cytometry; Cancer cell; Biology; Phenotype; Molecular biology; Biochemistry; Cancer; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254791,0.0002521925,0.0001571799,0.0001703261,0.0001076721,0.0002749874,0.0002524398,0.0004125818,0.0008241982],"category_scores_gemma":[0.000183271,0.0001511708,0.0001245809,0.0001271091,0.0002789403,0.0003032601,0.0002978718,0.0004840269,0.0002548475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566411,"about_ca_system_score_gemma":0.0001317658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000305618,"about_ca_topic_score_gemma":0.0006367447,"domain_scores_codex":[0.9999257,0.000007928274,0.000004460386,0.00002255361,0.00002472885,0.00001466216],"domain_scores_gemma":[0.9998777,0.00004070565,0.00004370412,0.00001012283,0.00001424701,0.00001339305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002243926,0.00000225778,0.00005810284,0.00001291896,0.000001135182,0.00001562408,0.00001106682,0.00007689833,0.9985572,0.0001140553,0.00001995983,0.001108274],"study_design_scores_gemma":[0.000002045924,0.00003960834,0.0002826724,0.00000127874,0.000002555236,0.00006051174,0.000008700915,0.0007954415,0.9981555,0.00005218608,0.0005976502,0.000001963288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453689,0.001730707,0.04892904,0.0001664296,0.00002552445,0.00003257549,0.0002432394,0.0002144838,0.00328918],"genre_scores_gemma":[0.9609685,0.001488367,0.03411586,0.0000945278,0.00001455241,0.00005094133,0.000175459,0.00004398522,0.003047844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008241982,"threshold_uncertainty_score":0.002757251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005417733687676195,"score_gpt":0.1982650363056249,"score_spread":0.1928473026179487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}