{"id":"W2521905552","doi":"10.1002/anie.201607483","title":"Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"In vivo; Mass cytometry; Oxygenation; Chemistry; Hypoxia (environmental); Biophysics; Cell biology; Flow cytometry; Cancer cell; Biology; Phenotype; Molecular biology; Biochemistry; Cancer; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008198782,0.0001623833,0.0001238146,0.0001440417,0.00002674551,0.00002130747,0.000165074,0.0001151128,0.0003064169],"category_scores_gemma":[0.00004038785,0.0001232165,0.00003514726,0.000136237,0.00006385281,0.0003816463,0.00002098372,0.0001144022,0.00004258783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006144284,"about_ca_system_score_gemma":0.00002649109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001988551,"about_ca_topic_score_gemma":0.00008198671,"domain_scores_codex":[0.9990847,0.000005297599,0.0002255524,0.0001955922,0.0002642014,0.0002246705],"domain_scores_gemma":[0.9996113,0.00005752845,0.00005208634,0.0001440795,0.00008972994,0.00004531482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006960116,0.00002723174,0.0001705319,0.00002908032,0.00003553355,0.00002284941,0.0000870636,0.0002570655,0.9960749,0.00008380714,0.002333656,0.000808694],"study_design_scores_gemma":[0.0008774272,0.00004875554,0.0003250386,0.000178327,0.00001045174,0.00002012512,0.00002170897,0.0005878417,0.9887882,0.001526624,0.007416007,0.0001994914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8298744,0.0003776166,0.1548396,0.001382102,0.003603089,0.0005186301,0.0003402815,0.0005898442,0.008474411],"genre_scores_gemma":[0.9976813,0.0001766387,0.0006033669,0.00004460817,0.0004821754,0.00005129509,0.0000854216,0.00004207329,0.0008330983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1678069,"threshold_uncertainty_score":0.5024623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005417733687676195,"score_gpt":0.1982650363056249,"score_spread":0.1928473026179487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}