{"id":"W2521908034","doi":"10.1038/mtna.2016.69","title":"Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Differentiated Intestinal Cells","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institutes of Health; Gebert Rüf Stiftung; Eidgenössische Technische Hochschule Zürich","keywords":"Transfection; Gene silencing; Nucleic acid; Chemistry; Oligonucleotide; Genetic enhancement; Cell culture; Molecular biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724951,0.0002714684,0.0002233978,0.0001044376,0.00008305372,0.0002150763,0.000126016,0.0002355714,0.0003435515],"category_scores_gemma":[0.0001229231,0.0001007244,0.0001386446,0.00009743514,0.0001557434,0.0001841271,0.0001378853,0.0002051909,0.0001237338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554742,"about_ca_system_score_gemma":0.0001320103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006014182,"about_ca_topic_score_gemma":0.0009799798,"domain_scores_codex":[0.9999071,0.00002472975,0.000008655449,0.00002000642,0.00002417528,0.00001524352],"domain_scores_gemma":[0.9999361,0.00001857541,0.00002045974,0.000006663903,0.00001015649,0.000008037419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009369649,0.000003044625,0.00002341368,0.000009538808,7.312057e-7,0.00000766937,0.000004904967,0.00003158528,0.999663,0.0000192239,0.000002133493,0.0002252781],"study_design_scores_gemma":[0.000001691064,0.00007534491,0.0002577347,0.000001032059,0.000002635168,0.00001912603,0.000003881637,0.0002283451,0.9990314,0.000004228302,0.000373731,9.004551e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994065,0.0005567147,0.004498648,0.00002156944,0.000006727971,0.00002733509,0.00007493598,0.00002898928,0.0007200813],"genre_scores_gemma":[0.9927019,0.0005108115,0.004872331,0.00002081523,0.000002783705,0.00002869941,0.0001665897,0.00001501981,0.001681066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006014182,"threshold_uncertainty_score":0.001853645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007369772765773766,"score_gpt":0.213785436691094,"score_spread":0.2064156639253202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}