{"id":"W2521908034","doi":"10.1038/mtna.2016.69","title":"Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Differentiated Intestinal Cells","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institutes of Health; Gebert Rüf Stiftung; Eidgenössische Technische Hochschule Zürich","keywords":"Transfection; Gene silencing; Nucleic acid; Chemistry; Oligonucleotide; Genetic enhancement; Cell culture; Molecular biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001875344,0.0004585116,0.0003588451,0.0001243038,0.00009092048,0.00006189907,0.0008720372,0.0003008311,0.0002338],"category_scores_gemma":[0.00006894314,0.0003607923,0.0002152392,0.0001924106,0.0002106194,0.00001779351,0.0002616552,0.0001729561,0.00007075164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000058464,"about_ca_system_score_gemma":0.00007421237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008853003,"about_ca_topic_score_gemma":0.00003054368,"domain_scores_codex":[0.9976457,0.0001794672,0.0004619884,0.0008001474,0.0002689496,0.0006437951],"domain_scores_gemma":[0.9985269,0.00002014664,0.0001425129,0.001003257,0.0001240195,0.00018319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002699893,0.0001214825,0.002703394,0.000007657215,0.000106668,0.00003901298,0.00009152917,0.00000528672,0.9877028,0.00001703673,0.001640756,0.007294365],"study_design_scores_gemma":[0.002439056,0.0007539119,0.001307043,0.00007624528,0.00001571462,0.00002262046,0.00005218236,0.0000341914,0.9917031,0.0002981437,0.002779873,0.0005179126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932499,0.003029968,0.002496072,0.0003940054,0.000229397,0.0002860399,0.0001111046,0.00005354751,0.00014996],"genre_scores_gemma":[0.9968218,0.001265627,0.0002499084,0.001009804,0.000102686,0.00004680605,0.0001009499,0.00009517888,0.0003072082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006776453,"threshold_uncertainty_score":0.9998844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007369772765773766,"score_gpt":0.213785436691094,"score_spread":0.2064156639253202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}