{"id":"W2521939468","doi":"10.1074/jbc.m116.736215","title":"A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Intracellular pH; Cytoplasm; Histidine; Intracellular; Wild type; Chemistry; Mutant; Phosphatidylinositol; Sodium–hydrogen antiporter; Pi; Biochemistry; Alanine; Arginine; Binding site; Biology; Molecular biology; Cell biology; Amino acid; Phosphorylation; Sodium; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005894006,0.0001968981,0.0001632926,0.0001239363,0.0001902525,0.0001616338,0.0001512314,0.0002210165,0.002176807],"category_scores_gemma":[0.00009072165,0.0001041744,0.0001410129,0.0001359321,0.0001564566,0.0001600205,0.0002028569,0.0003311309,0.001077246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004006099,"about_ca_system_score_gemma":0.000165703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009412845,"about_ca_topic_score_gemma":0.00122101,"domain_scores_codex":[0.9999417,0.000008009215,0.000003715194,0.00001748269,0.00001436034,0.0000148381],"domain_scores_gemma":[0.9999248,0.00001339428,0.00001595587,0.000007983868,0.000007783481,0.0000301557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002921493,0.00001400511,0.0002351508,0.00004015267,0.000002794946,0.00009934166,0.00001346871,0.00009410369,0.9970796,0.0001658855,0.0001905594,0.001772727],"study_design_scores_gemma":[0.0001335964,0.0004273031,0.06268614,0.00002771488,0.00003659397,0.001461714,0.00008346047,0.003200024,0.9185242,0.0003333701,0.01305671,0.00002918221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934522,0.000602666,0.002865653,0.0001476241,0.00003551649,0.00001918543,0.001041205,0.0001328321,0.00170316],"genre_scores_gemma":[0.9921638,0.0002666638,0.002146973,0.00005386789,0.00001293543,0.000009772124,0.001697167,0.00003557474,0.003613289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002176807,"threshold_uncertainty_score":0.007282197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297228253588355,"score_gpt":0.2173985179324071,"score_spread":0.2044262353965236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}