{"id":"W2521974675","doi":"10.1038/mtm.2016.51","title":"PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of General Medical Sciences; National Eye Institute","keywords":"PAX6; Aniridia; Biology; Retina; Adeno-associated virus; Genetic enhancement; Gene expression; Retinal; Cell biology; Genetics; Gene; Neuroscience; Vector (molecular biology); Recombinant DNA; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003437908,0.0004959244,0.0002416626,0.000499377,0.0002167074,0.0003199818,0.0004609887,0.0003850899,0.002228871],"category_scores_gemma":[0.0002075407,0.0004120501,0.0003087154,0.000146992,0.0003498946,0.0002954536,0.000333072,0.0009064655,0.00131566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002430928,"about_ca_system_score_gemma":0.0002934458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002986282,"about_ca_topic_score_gemma":0.0006317141,"domain_scores_codex":[0.99968,0.00004377962,0.00004307335,0.00008322407,0.0001052261,0.00004469455],"domain_scores_gemma":[0.9997807,0.00004420527,0.0000782391,0.00003173781,0.00001950609,0.00004563286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004086054,0.00001857583,0.00008966138,0.00002281916,0.000002505847,0.00002382022,0.00001744612,0.00009107334,0.997574,0.0002736932,0.00004292537,0.001802459],"study_design_scores_gemma":[0.0000252731,0.0002513294,0.001062597,0.000015867,0.00001307942,0.0002444406,0.00002084102,0.0007642522,0.9922404,0.000109017,0.005247479,0.000005233735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9061682,0.002308498,0.07819373,0.0002622979,0.0001065036,0.0005556248,0.002172272,0.001472549,0.008760233],"genre_scores_gemma":[0.8909935,0.00290658,0.0827764,0.0001807521,0.00003095322,0.0006318164,0.003222244,0.0004606603,0.01879718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002228871,"threshold_uncertainty_score":0.007456362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03744965505592205,"score_gpt":0.3803904842790558,"score_spread":0.3429408292231337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}