{"id":"W2522197822","doi":"10.1128/aac.01436-16","title":"Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Amide; Enzyme; Plasmodium falciparum; Coenzyme A; Biosynthesis; Biochemistry; Potency; Kinase; In vivo; Phosphorylation; Chemistry; Drug discovery; Transferase; Stereochemistry; Biology; Structure–activity relationship; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008619392,0.0002800024,0.0002685149,0.000196259,0.0001181924,0.0001325199,0.0002736883,0.0002382587,0.00269488],"category_scores_gemma":[0.0001418435,0.00008839636,0.0001703407,0.0001850106,0.0001457996,0.0001817783,0.00009649636,0.0002874076,0.0004362433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045508,"about_ca_system_score_gemma":0.000169082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008590794,"about_ca_topic_score_gemma":0.001560451,"domain_scores_codex":[0.9999312,0.00001101801,0.000007731087,0.00001090756,0.00001771994,0.00002130812],"domain_scores_gemma":[0.9999288,0.000009641743,0.00001854419,0.000008758369,0.00001628629,0.00001788699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001952005,0.00006938203,0.0001379353,0.00004288512,0.000009484716,0.00006914476,0.00001219693,0.0001919719,0.9962281,0.00005622159,0.00009780889,0.002889562],"study_design_scores_gemma":[0.00009899284,0.002588895,0.003295673,0.000007411566,0.00003876131,0.0003701063,0.00001741585,0.0007474272,0.9893246,0.00002934016,0.003472584,0.00000876943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940026,0.001408464,0.00108289,0.00007763005,0.00002535336,0.00005625897,0.0003024982,0.00009640231,0.002947749],"genre_scores_gemma":[0.9962589,0.0007873824,0.001236136,0.00004648475,0.000008217042,0.00001705334,0.0003111814,0.00001342731,0.001321222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00269488,"threshold_uncertainty_score":0.009015262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003554302590233,"score_gpt":0.2386474074782355,"score_spread":0.2186118644523332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}